Dorzolamide EP Impurity B（R,S-Isomer) CAS 149249-72-9
| CAS No. | 149249-72-9 |
| Molecular Formula | C10H16N2O4S3 |
| Molecular Weight | 324.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Dorzolamide EP Impurity B（R,S-Isomer) (CAS 149249-72-9, C10H16N2O4S3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C10H16N2O4S3, Dorzolamide EP Impurity B（R,S-Isomer) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 324.44 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H16N2O4S3 |
| Molecular Weight | 324.44 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 3 |
Related Dorzolamide Standards
Recommended Standards
- 14,14-Dimethyl-10-(thiophen-2-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6-tetraen-12-one (CAS 145628-73-5)
- S-(2-hydroxyethyl) 4-(5,5-diethyl-1,3-dioxan-2-yl)benzothioate (CAS 1569627-69-5)
- N1-(2-Hydroxy-2-methyl-4-(methylthio)butyl)-N2-phenethyloxalamide (CAS 1421531-74-9)
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- Lemborexant impurity 9 (CAS 1369763-94-9)
- Ilaprazole Impurity 178 (CAS CATO-C4X-1130178)
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- 3-Fluorotoluene-α,α,α-d3 (CAS 4202-92-0)
- N-(4-(2-(allylamino)thiazol-4-yl)phenyl)acetamide hydrobromide (CAS 1274903-95-5)
- 3-Methoxytetrahydro-2H-pyran-4-carbaldehyde (CAS 1879795-69-3)
- 4-Bromo-N-(piperidin-4-yl)benzamide hydrochloride (CAS 1233952-50-5)
- 3-(Aminomethyl)-6-(difluoromethyl)-5-iodopyridin-2-amine (CAS 1803670-98-5)
- (9-D-Asp) Semaglutide X Sodium salt (CAS CATO-CPTD788617)
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