Dorzolamide EP Impurity A CAS 120279-95-0
| CAS No. | 120279-95-0 |
| Molecular Formula | C10H16N2O4S3 |
| Molecular Weight | 324.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Dorzolamide EP Impurity A (CAS 120279-95-0) is a certified pharmaceutical impurity reference standard with the molecular formula C10H16N2O4S3 and a molecular weight of 324.44 g/mol.
Dorzolamide EP Impurity A (C10H16N2O4S3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H16N2O4S3 |
| Molecular Weight | 324.44 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 3 |
Related Dorzolamide Standards
- Dorzolamide (CAS 120279-96-1)
- Rac-Dorzolamide (CAS 120280-13-9)
- Dorzolamide (CAS 139066-77-6)
- Dorzolamide EP Impurity B（R,S-Isomer) (CAS 149249-72-9)
- Dorzolamide Impurity 3 (CAS CATO-C4X-12283)
- Dorzolamide Impurity 13 (CAS 897657-78-2)
- Dorzolamide-d5 (CAS 1227097-70-2)
- Dorzolamide Impurity 22 (CAS 147128-79-8)
Recommended Standards
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