Lisinopril impurity 29 CAS 1496563-44-0
| CAS No. | 1496563-44-0 |
| Molecular Formula | C18H20N2O4 |
| Molecular Weight | 328.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lisinopril impurity 29.
As a process- or degradation-related impurity, Lisinopril impurity 29 (CAS 1496563-44-0, C18H20N2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lisinopril impurity 29 (C18H20N2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lisinopril impurity 29 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H20N2O4 |
| Molecular Weight | 328.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Nitrogen Atoms | 2 |
Related Lisinopril Standards
- Lisinopril Impurity 11 (CAS CATO-C4X-168111)
- Lisinopril EP Impurity H (CAS 138247-43-5)
- Lisinopril (8R,S)-Diketopiperazine (Mixture of Diastereomers) (CAS 1092813-99-4)
- Lisinopril EP Impurity C (CAS 328385-86-0)
- Lisinopril EP Impurity D (CAS 219677-82-4)
- Lisinopril Impurity 28 (CAS 1207346-27-7)
- Lisinopril (CAS 76547-98-3)
- Lisinopril EP Impurity E (CAS 85955-59-5)
Recommended Standards
- Ketoprofen Impurity 30 (CAS CATO-C4X-147130)
- Esmolol Impurity 42 (CAS CATO-C4X-189142)
- Flurbiprofen Impurity 35 (CAS CATO-C4X-144435)
- Dopamine Impurity 96 (CAS CATO-C4X-190896)
- Febuxostat impurity 125 (CAS CATO-C4X-1162101)
- 34-Methylcyanocobalamin(Cyanocobalamin EP Impurity C） (CAS 38218-51-8)
- Crisaborole Impurity 50 (CAS CATO-C4X-202150)
- 3-(Heptylamino)-N-methylpropanamide (CAS 1040690-26-3)
- 2-AMino-5-(4-bromo-phenyl)-thiazole-4-carboxylic acid (CAS 1269503-17-4)
- Methyl 2-acetamido-4-O-(2-acetamido-3-4-6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-2-deoxy-β-D-glucopyranoside (CAS 97242-82-5)
- Methyl 4-(4-Boc-1-piperazinyl)-2-chlorobenzoate (CAS 1346597-59-8)
- Methyl 2-bromo-8-methoxyindolizine-7-carboxylate (CAS 1706460-06-1)
- 2-Amino-N-(4-(N-cyclopropylacetamido)cyclohexyl)acetamide (CAS 1353946-23-2)
- Semaglutide-d5 (CAS CATO-C4X-2226153)
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