Lisinopril Impurity 28 CAS 1207346-27-7
| CAS No. | 1207346-27-7 |
| Molecular Formula | C13H20BNO4 |
| Molecular Weight | 265.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 265.11 g/mol gives Lisinopril Impurity 28 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Lisinopril Impurity 28 (CAS 1207346-27-7, C13H20BNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Lisinopril Impurity 28 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 265.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H20BNO4 |
| Molecular Weight | 265.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 1 |
Related Lisinopril Standards
- Lisinopril Impurity 12 (CAS CATO-C4X-168112)
- Lisinopril EP Impurity H (CAS 138247-43-5)
- Lisinopril impurity 29 (CAS 1496563-44-0)
- Lisinopril EP Impurity A (CAS 5472-95-7)
- Lisinopril Impurity 11 (CAS CATO-C4X-168111)
- Lisinopril EP Impurity A (CAS 1012-05-1)
- Lisinopril (8R,S)-Diketopiperazine (Mixture of Diastereomers) (CAS 1092813-99-4)
- Lisinopril EP Impurity C (CAS 328385-86-0)
Recommended Standards
- Pyrrolo[2,1-b]quinazolin-9(1H)-one (CAS 61938-65-6)
- Ifosfamide-d4 (CAS 1189701-13-0)
- N2-(6-Bromopyridin-2-yl)pyridine-2,6-diamine (CAS 427900-26-3)
- 2-(3-Bromobenzenesulfonyl)ethanol (CAS 1021169-75-4)
- Nintedanib Impurity 41 (CAS 121-95-9)
- Ixabepilone Impurity 3 (CAS 219989-85-2)
- Desmopressin Tyrosine Oxidation Impurity 2 (CAS CATO-C4X-221519)
- Mitiglinide Impurity 18 (CAS 145324-19-2)
- 2,5-Dichloro-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (CAS 2090969-59-6)
- Ethyl 5-(hydroxymethyl)-5-methyl-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxylate (CAS 2413409-70-6)
- (5-BRomo-2-chloro-6-methyl-pyridin-3-yl)-methanol (CAS 1936227-62-1)
- Palbociclib Impurity 11 (CAS CATO-C4X-112511)
- 6-Iodo-[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one (CAS 690258-19-6)
- Acetyl decapeptide-3 (CAS 935288-50-9)
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