Valsartan Impurity 70 CAS 149690-13-1
| CAS No. | 149690-13-1 |
| Molecular Formula | C20H25NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Valsartan Impurity 70 (CAS 149690-13-1) is a certified pharmaceutical impurity reference standard with the molecular formula C20H25NO2HCl and a molecular weight of 347.88 g/mol.
Structurally, Valsartan Impurity 70 (C20H25NO2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 347.88 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Valsartan Impurity 70 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H25NO2 HCl |
| Molecular Weight | 347.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Valsartan Standards
- Valsartan Impurity 121 (CAS 1000986-63-9)
- (S)-(-)-Valsartan-d8 (valine-d8) (CAS 1089736-72-0)
- Valsartan-d9 (Major) (CAS 1089736-73-1)
- Valsartan Impurity 13 ( Valproic Acid EP Impurity A ) (CAS 109-52-4)
- Valsartan Impurity 35 HCl (CAS 1111177-20-8)
- Valsartan Impurity 9 (CAS 1111177-30-0)
- Valsartan Impurity 10 (CAS 114772-54-2)
- Valsartan Impurity 82 (CAS 1189547-11-2)
Recommended Standards
- Nicardipine Impurity 53 (CAS CATO-C4X-171053)
- Finerenone Impurity 127 (CAS CATO-C4X-2880127)
- Selexipag Impurity 2 D6 (CAS 1265295-56-4)
- 7-Methyl-2H-indazol-6-amine (CAS 208457-82-3)
- 6-Methoxy-2,3,4,5-tetrahydropyridine (CAS 5693-62-9)
- N-(2-(1H-pyrazol-3-yl)benzofuran-3-yl)acetamide (CAS 1401785-89-4)
- Rifampicin Impurity 4 (CAS 16783-99-6)
- 1,5-Dimethoxypentane (CAS 111-89-7)
- 1-Butyl-2,3-dimethyl-1H-imidazol-3-ium iodide (CAS 108203-70-9)
- Endo-Ala35-Tirzepatide (CAS CATO-CPTD788687)
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