LCZ-696 Impurity 57 CAS 149709-58-0
| CAS No. | 149709-58-0 |
| Molecular Formula | C20H23NO3 |
| Molecular Weight | 325.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, LCZ-696 Impurity 57 (CAS 149709-58-0, C20H23NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H23NO3, LCZ-696 Impurity 57 contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 325.40 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H23NO3 |
| Molecular Weight | 325.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 1 |
Recommended Standards
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- LCZ-696 Impurity 81 (CAS CATO-C4X-169681)
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- 2-Bromo-6-fluoropyridin-4-amine (CAS 1803125-88-3)
- 2-(Aminomethyl)benzo[d]oxazole-6-methanol (CAS 1806303-31-0)
- tert-Butyl 2-bromo-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazine-7(8H)-carboxylate (CAS 1575613-02-3)
- 1-(2,6-Difluorophenyl)cyclobutan-1-ol (CAS 935287-84-6)
- Colchicine EP Impurity G (CAS 6901-14-0)
- Cycloaspeptide D (CAS 691363-62-9)
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