Flurbiprofen Impurity 87 CAS 65487-32-3
| CAS No. | 65487-32-3 |
| Molecular Formula | C9H9FO2 |
| Molecular Weight | 168.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Flurbiprofen Impurity 87 (C9H9FO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Flurbiprofen Impurity 87 (CAS 65487-32-3, C9H9FO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Flurbiprofen Impurity 87 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9FO2 |
| Molecular Weight | 168.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 89 (CAS 75908-73-5)
- Flurbiprofen Impurity 42 (CAS CATO-C4X-144442)
- Flurbiprofen Impurity 54 (CAS 1845-59-6)
- Flurbiprofen Impurity 56 (CAS 5563-78-0)
- Flurbiprofen Impurity 41 (CAS 535-11-5)
- Flurbiprofen Impurity 23 (CAS 399-31-5)
- Flurbiprofen Impurity N1 (CAS 81937-33-9)
- Flurbiprofen Impurity 9 (CAS 477860-13-2)
Recommended Standards
- Temozolomide Impurity 4 (CAS 3413-72-7)
- Metformin EP Impurity B (CAS 4405-08-7)
- Tegoprazan Impurity 100 (CAS CATO-C4X-2297100)
- Ethyl 4-fluorobenzoate (CAS 451-46-7)
- Cefprozil EP Impurity H (CAS CATO-C4X-149214)
- Aspirin impurity 30 (CAS 85531-18-6)
- Levamisole EP Impurity D (CAS 4335-28-8)
- 4-(4-Methylbenzyl)piperidin-4-ol (CAS 192990-05-9)
- Proparacaine Impurity 6 (CAS 59691-15-5)
- Nadolol (CAS 42200-33-9)
- (Z)-5-((2E,4E,6E,12E)-Tetradeca-2,4,6,12-tetraen-8,10-diyn-1-ylidene)furan-2(5H)-one (CAS 132971-61-0)
- Ethyl 5-(1,1-difluoroethyl)isoxazole-3-carboxylate (CAS 861136-14-3)
- 3-(4-Methoxyphenyl)-4-methyl-5-(methylthio)-4H-1,2,4-triazole (CAS 57295-61-1)
- D-Tyr1-Tirzepatide (CAS CATO-CPTD788928)
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