Salbutamol Impurity N19 CAS 77430-27-4
| CAS No. | 77430-27-4 |
| Molecular Formula | C24H29NO5 |
| Molecular Weight | 411.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Salbutamol Impurity N19.
As a process- or degradation-related impurity, Salbutamol Impurity N19 (CAS 77430-27-4, C24H29NO5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C24H29NO5, Salbutamol Impurity N19 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 411.49 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H29NO5 |
| Molecular Weight | 411.49 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Nitrogen Atoms | 1 |
Related Salbutamol Standards
- Salbutamol Impurity 195 (CAS CATO-C4X-1176195)
- Salbutamol Impurity 184 (CAS CATO-C4X-1176184)
- Salbutamol Impurity 185 (CAS CATO-C4X-1176185)
- Salbutamol Impurity 78 (CAS CATO-C4X-117678)
- Salbutamol Impurity P (CAS CATO-C4X-1176161)
- Salbutamol Impurity 222 (CAS CATO-C4X-1176222)
- Salbutamol Impurity 173 (CAS CATO-C4X-1176173)
- Salbutamol Impurity 180 (CAS CATO-C4X-1176180)
Recommended Standards
- Sacubitril impurity 54 (CAS 149709-63-7)
- Fmoc-N-Me-Thr(tBu)-OH (CAS 117106-20-4)
- Sacubitril impurity 45 (CAS 761373-05-1)
- lasiocarpine (CAS 303-34-4)
- Voclosporin Impurity 1 (CAS CATO-C4X-30651)
- Mometasone Impurity 29 (CAS 83880-63-1)
- Azithromycin impurity 60 (CAS CATO-C4X-100360)
- 4-(Difluoromethyl)-2,5-dimethoxypyridin-3-ol (CAS 1805285-14-6)
- Metoclopramide Impurity 35 (CAS CATO-C4X-141535)
- 4-(1,3-thiazol-5-yl)butanoic acid (CAS 933686-34-1)
- 1,5-Diamino-4-(4-(4-fluorophenyl)thiazol-2-yl)-1,2-dihydro-3h-pyrrol-3-one (CAS 885524-40-3)
- Raltegravir EthyIEster of Hydrazonic Acid (CAS CATO-C4X-26156)
- 1-(3-Methylbutyl)-5-oxopyrrolidine-3-carboxylic acid (CAS 944648-73-1)
- [3-31]-Semaglutide D (Sodium salt) (CAS CATO-C4X-2226119)
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