Sacubitril Impurity 20 CAS 2459446-51-4
| CAS No. | 2459446-51-4 |
| Molecular Formula | C25H31NO5 |
| Molecular Weight | 425.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Sacubitril Impurity 20 (CAS 2459446-51-4) is a certified pharmaceutical impurity reference standard with the molecular formula C25H31NO5 and a molecular weight of 425.52 g/mol.
The molecular framework of Sacubitril Impurity 20 (C25H31NO5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C25H31NO5 |
| Molecular Weight | 425.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Nitrogen Atoms | 1 |
Related Sacubitril Standards
- Sacubitril Impurity 37 (CAS CATO-C4X-280937)
- Sacubitril impurity 48 (CAS 2984580-04-1)
- Sacubitril impurity 19 (CAS CATO-C4X-280919)
- Sacubitril-d4 (CAS 1884269-07-1)
- Sacubitril Impurity 29 (CAS CATO-C4X-280929)
- Sacubitril Impurity 32 (CAS CATO-C4X-280932)
- Sacubitril impurity 45 (CAS 761373-05-1)
- Sacubitril impurity 54 (CAS 149709-63-7)
Recommended Standards
- LCZ-696 Impurity 11 (CAS CATO-C4X-169611)
- Valsartan Impurity 146 (CAS CATO-C4X-1057146)
- tert-butyl N-(tert-butoxycarbonylamino)-N-[3-(4-nitrophenyl)-1-bicyclo[1.1.1]pentanyl]carbamate (CAS 2149634-57-9)
- Metaxalone Impurity 4 (CAS CATO-C4X-30054)
- Iomeprol Impurity 4 (CAS 2068038-50-4)
- Suzetrigine Impurity 32 (CAS CATO-C4X-336932)
- Pitavastatin Impurity 127 (CAS CATO-C4X-1037127)
- Furan-3-yl(4-propylphenyl)methanol (CAS 1247457-70-0)
- n-Cyclohexyl-3-phenylpropanamide (CAS 10264-23-0)
- 3-Methoxy-4-(trifluoromethyl)benzoic Acid (CAS 276861-63-3)
- 4-(Methoxymethyl)oxane-4-carbaldehyde (CAS 1824316-03-1)
- Clenhexerol (CAS 78982-88-4)
- H-Leu-Gly-Oet (CAS 53375-57-8)
- Tirzepatide Impurity 11 TFA salt (CAS CATO-C4X-324011)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com