Trandolapril EP Impurity D CAS 149881-40-3
| CAS No. | 149881-40-3 |
| Molecular Formula | C24H32N2O4 |
| Molecular Weight | 412.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Trandolapril EP Impurity D is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Trandolapril EP Impurity D (CAS 149881-40-3) is a certified pharmaceutical impurity reference standard with the molecular formula C24H32N2O4 and a molecular weight of 412.52 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Trandolapril EP Impurity D is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 412.52 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H32N2O4 |
| Molecular Weight | 412.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 2 |
Related Trandolapril Standards
- Trandolapril EP Impurity A (CAS 118194-41-5)
- Trandolapril EP Impurity E (Trandolaprilate) (CAS 87679-71-8)
- Trandolapril (CAS 87679-37-6)
- Trandolapril-D5 (CAS 1356847-98-7)
- rac-Trandolapril D5 (CAS CATO-C4X-177017)
- Trandolapril impurity (CAS CATO-C4X-177016)
- Trandolapril Benzyl Ester (CAS 98677-37-3)
- Trandolapril Impurity 14 (CAS CATO-C4X-177014)
Recommended Standards
- 4-(4-(4-Fluorophenyl)-5-(2-(propylthio)pyrimidin-4-yl)-1h-imidazol-1-yl)cyclohexanol (CAS 1455432-05-9)
- N4,N4,N4'-Triphenyl-[1,1'-biphenyl]-4,4'-diamine (CAS 167218-30-6)
- (1R)-1-[(2R,3R,4R)-3-(benzoyloxy)-4-hydroxy-5-methoxy-4-methyloxolan-2-yl]ethyl benzoate (CAS 1417563-67-7)
- 4-(Anthracen-2-yl)-1,1-diphenylpent-2-yn-1-ol (CAS 17939-06-9)
- Istradefylline impurity 31 (CAS CATO-C4X-106131)
- Gefitinib Impurity 22 (CAS 52805-46-6)
- Ornidazole Impurity 31 (CAS 57939-59-0)
- Ethyl 3-(benzylamino)-3-oxopropanoate (CAS 29689-63-2)
- (2S)-1-pyrrolidinesulfonamide (CAS 4108-88-7)
- 2-(3-Nitrophenoxy)quinoxaline (CAS 197522-02-4)
- Gadoxetate Impurity 15 (CAS CATO-C4X-261816)
- Ketoprofen Impurity 40 (CAS 47087-07-0)
- But-2-yn-1-ylbenzene (CAS 33598-22-0)
- Liraglutide(14-22)TFA Salt (CAS CATO-C4X-199212)
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