Posaconazole impurity 226 CAS CATO-C4X-1208226
| CAS No. | CATO-C4X-1208226 |
| Molecular Formula | C16H20F2O3 |
| Molecular Weight | 298.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 298.33 g/mol gives Posaconazole impurity 226 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Posaconazole impurity 226 (CAS CATO-C4X-1208226) is a certified pharmaceutical impurity reference standard with the molecular formula C16H20F2O3 and a molecular weight of 298.33 g/mol.
The molecular framework of Posaconazole impurity 226 (C16H20F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Posaconazole impurity 226 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H20F2O3 |
| Molecular Weight | 298.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Posaconazole Standards
- Posaconazole Impurity 106 (CAS 192448-07-0)
- Posaconazole Impurity 104 (CAS CATO-C4X-1208104)
- Posaconazole impurity 253 (CAS CATO-C4X-1208253)
- Posaconazole Impurity 111 (CAS 112559-81-6)
- Posaconazole Impurity 123 (CAS 149882-18-8)
- Posaconazole impurity 235 (CAS CATO-C4X-1208235)
- Posaconazole Impurity 55 (CAS CATO-C4X-120855)
- Posaconazole Impurity 57 (CAS 160709-02-4)
Recommended Standards
- Flurbiprofen Impurity 93 (CAS CATO-C4X-144493)
- Dapagliflozin Impurity 38 (CAS 2132-59-4)
- Carglumic Acid impurity 7 (CAS 219844-08-3)
- Dapagliflozin Impurity 148 (CAS 342043-51-0)
- Polaprezinc Impurity 18 (CAS CATO-C4X-182118)
- Faropenem Impurity 81 (CAS CATO-C4X-128981)
- Azilsartan Impurity 187 (CAS CATO-C4X-1096187)
- (Z)-{[2-(2H-1,3-benzodioxol-5-yl)cyclopropyl](4-methoxyphenyl)methylidene}amino 2,4-dichlorobenzoate (CAS 338749-23-8)
- 1-(9H-purin-6-yl)piperidin-4-ol (CAS 537667-08-6)
- 5-Bromo-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile (CAS 1269291-51-1)
- 5,7-Dimethylbenzofuran-2,3-dione (CAS 31297-28-6)
- 4-Methyl-2-(1H-pyrrol-1-yl)pyridin-3-amine (CAS 120494-06-6)
- 3-Fluorophenethyl acetate (CAS 59163-71-2)
- Acetyl-Tau Peptide (244-274) (Repeat 1 Domain) trifluoroacetate salt (CAS 2022956-56-3)
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