Abemaciclib impurity 104 CAS 150807-86-6
| CAS No. | 150807-86-6 |
| Molecular Formula | C6H7Cl2NO |
| Molecular Weight | 180.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Abemaciclib impurity 104.
CATO supplies Abemaciclib impurity 104 (CAS 150807-86-6), a pharmacopoeial impurity reference standard (molecular formula C6H7Cl2NO, MW 180.03 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Abemaciclib impurity 104 is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 180.03 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Abemaciclib impurity 104 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H7Cl2NO |
| Molecular Weight | 180.03 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Abemaciclib Standards
- Abemaciclib impurity 116 (CAS CATO-C4X-2937116)
- Abemaciclib Impurity 2 (CAS 1528469-78-4)
- Abemaciclib Impurity 36 (CAS CATO-C4X-293736)
- Abemaciclib Impurity 7 (CAS 414881-11-1)
- Abemaciclib Impurity 24 (CAS CATO-C4X-293724)
- Abemaciclib Impurity 61 (CAS 827587-92-8)
- Abemaciclib Impurity 1 (CAS CATO-C4X-29371)
- Abemaciclib Impurity 181 (CAS CATO-C4X-2937181)
Recommended Standards
- 6-Chloro-3,4-dihydro-1(2H)-pyridinecarbonyl chloride (CAS 5100-15-2)
- (4,5-Dichloro-1-methyl-1H-pyrazol-3-yl)methanamine (CAS 1006320-03-1)
- 2-Chloro-5-cyanopentanoyl chloride (CAS 89466-72-8)
- 2-Bromo-N-ethyl-N-methylacetamide (CAS 119152-89-5)
- Lornoxicam Impurity 79 (CAS 1629463-16-6)
- Avibactam Impurity 26 (CAS CATO-C4X-134826)
- Mivacurium chloride Impurity 46 (CAS CATO-C4X-137546)
- 2,3-Dichloro-5-(difluoromethyl)-4-iodopyridine (CAS 1805327-79-0)
- 3,6,9,12,15,18-Hexaoxanonacos-28-en-1-ol (CAS 130727-48-9)
- 5-(Trifluoromethyl)benzo[d]isothiazol-3(2H)-one (CAS 159803-18-6)
- 2-(3-(2-Chloro-4-(chlorosulfonyl)phenyl)ureido)pyridin-1-ium hydrogen sulfate (CAS 820245-41-8)
- 2,6,8-Trimethylquinoline-3-carboxylic acid (CAS 876721-02-7)
- 8-Bromoquinazoline-4-acetic Acid (CAS 1785367-89-6)
- D-[γ-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226254)
Why CATO?
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