Methylprednisolone Acetate EP Impurity D CAS 150899-33-5
| CAS No. | 150899-33-5 |
| Molecular Formula | C22H30O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Methylprednisolone Acetate EP Impurity D (CAS 150899-33-5, C22H30O5C22H28O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Methylprednisolone Acetate EP Impurity D (C22H30O5C22H28O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H30O5 C22H28O4 |
| Molecular Weight | 730.94 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
Related Methylprednisolone Standards
- Methylprednisolone Impurity 72 (CAS 1012306-79-4)
- Methylprednisolone impurity 96 (CAS 103302-98-3)
- Methylprednisolone Impurity 57 (CAS 1048031-80-6)
- Methylprednisolone Acetate EP Impurity J (CAS 1048031-82-8)
- Methylprednisolone impurity 87 (CAS 105500-05-8)
- Methylprednisolone impurity 82 (CAS 106502-98-1)
- Methylprednisolone Acetate EP Impurity K (CAS 115321-98-7)
- Methylprednisolone Hydrogen Succinate EP Impurity D (CAS 119657-85-1)
Recommended Standards
- Ivacaftor Impurity 10 (CAS 873055-58-4)
- Lifitegrast Impurity 155 (CAS CATO-C4X-2409155)
- Difelikefalin Impurity 80 (CAS CATO-C4X-304180)
- 2-Chloro-6-(1-methylhydrazinyl)-4-(trifluoromethyl)pyridine (CAS 1053659-61-2)
- (S)-2-((benzyloxy)carbonyl)-2,8-diazaspiro[4.5]Decane-3-carboxylic acid (CAS 2306247-66-3)
- 2,4-Dioxopentan-3-yl acetate (CAS 18632-38-7)
- (S)-3-amino-2-(benzylamino)propan-1-ol (CAS 1260587-77-6)
- methyl 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate (CAS CATO-C4X-1063141)
- Benzyl (1S)-1-((dimethylamino)methyl)-3-azabicyclo[3.1.0]Hexane-3-carboxylate (CAS 1268515-25-8)
- Semaglutide impurity 45 (CAS CATO-C4X-222645)
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