Entacapone Impurity 2 CAS 150995-46-3
| CAS No. | 150995-46-3 |
| Molecular Formula | C12H11N3O5 |
| Molecular Weight | 277.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Entacapone Impurity 2 (CAS 150995-46-3) is a certified pharmaceutical impurity reference standard with the molecular formula C12H11N3O5 and a molecular weight of 277.23 g/mol.
Structurally, Entacapone Impurity 2 (C12H11N3O5) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 277.23 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H11N3O5 |
| Molecular Weight | 277.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Nitrogen Atoms | 3 |
Related Entacapone Standards
- Entacapone Impurity 01 (CAS 116314-52-4)
- Entacapone EP Impurity B (CAS 1215039-66-9)
- Entacapone Impurity 72 (CAS 893419-47-1)
- Entacapone Impurity 36 (CAS CATO-C4X-162936)
- Entacapone impurity 52 (CAS CATO-C4X-162952)
- Entacapone impurity 18 (CAS CATO-C4X-162918)
- Entacapone EP Impurity G (CAS 1364322-41-7)
- Entacapone Impurity 12 (CAS CATO-C4X-162912)
Recommended Standards
- 4-(2-Carboxyethyl)-4-nitroheptanedioic acid 4-(2-Carboxyethyl)-4-nitropimelic acid 59085-15-3 Nitromethanetrispropionic acid Tris(2-carboxyethyl)nitromethane (CAS 59085-15-3)
- Mizoribine Impurity 4 (CAS CATO-C4X-17024)
- 2902-98-9 Acetyl chloride, chlorodiphenyl- Benzeneacetyl chloride, alpha-chloro-alpha-phenyl- (9CI) alpha-Chloro-alpha,alpha-diphenylacetyl chloride 3-09-00-03308 (Beilstein Handbook Reference) AI3-16120 BRN 0981727 Chlorodiphenylacetyl chloride alpha-Chloro-alpha-phenylbenzeneacetyl chloride Diphenylchloroacetylchloride EINECS 220-798-6 NSC 400463 (CAS 2902-98-9)
- Fenitrothion (CAS 122-14-5)
- Empagliflozin impurity 61 (CAS CATO-C4X-1065261)
- Olaparib Impurity 165 (CAS CATO-C4X-1135165)
- Sulfadimethoxine EP Impurity D (CAS 121-57-3)
- n-Isopropyl-2,6-dimethylcyclohexan-1-amine (CAS 92142-28-4)
- (3S)-3-Benzyl-1-methylpiperazine dihydrochloride (CAS 898044-42-3)
- Fmoc-D-Tyr(tBu)-OH (CAS 118488-18-9)
- 3-Chloro-N-(3-(5,7-dimethylbenzo[d]oxazol-2-yl)-2-methylphenyl)benzamide (CAS 590395-76-9)
- 4-Methoxy-2-(pyrrolidin-1-ylmethyl)phenylboronic acid (CAS 1451392-11-2)
- 3-(Diethylamino)isobenzofuran-1(3H)-one (CAS 114259-16-4)
- Rac1 Inhibitor F56, control peptide (CAS 1315378-77-8)
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