Levofloxacin Desethylene Diformyl Impurity CAS 151377-74-1
| CAS No. | 151377-74-1 |
| Molecular Formula | C18H18FN3O6 |
| Molecular Weight | 391.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Levofloxacin Desethylene Diformyl Impurity.
Levofloxacin Desethylene Diformyl Impurity (CAS 151377-74-1) is a certified pharmaceutical impurity reference standard with the molecular formula C18H18FN3O6 and a molecular weight of 391.35 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Levofloxacin Desethylene Diformyl Impurity is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 391.35 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18FN3O6 |
| Molecular Weight | 391.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Levofloxacin Standards
- Levofloxacin Hemihydrate EP Impurity H (CAS 177472-30-9)
- Levofloxacin Impurity 38 (CAS 2130840-92-3)
- Levofloxacin Impurity 84 (CAS CATO-C4X-137184)
- Levofloxacin Impurity 63 (CAS CATO-C4X-137163)
- Levofloxacin Impurity 86 (CAS CATO-C4X-137186)
- Levofloxacin impurity 68 (CAS CATO-C4X-137168)
- Levofloxacin Impurity 53 (CAS CATO-C4X-137153)
- Levofloxacin Impurity 55 (CAS CATO-C4X-137155)
Recommended Standards
- 73485-90-2 1,2,3,4,6-Penta-O-acetyl-beta-D-(C~1~-~2~H)glucopyranose DTXSID40481738 (CAS 73485-90-2)
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