Vonoprazan Impurity N3 CAS 15177-57-8
| CAS No. | 15177-57-8 |
| Molecular Formula | C5H3Cl2NO |
| Molecular Weight | 163.99 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Vonoprazan Impurity N3 (C5H3Cl2NO) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Vonoprazan Impurity N3 (CAS 15177-57-8) is a certified pharmaceutical impurity reference standard with the molecular formula C5H3Cl2NO and a molecular weight of 163.99 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3Cl2NO |
| Molecular Weight | 163.99 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Vonoprazan Standards
- Vonoprazan Impurity 10 (CAS 122453-85-4)
- Vonoprazan Fumarate Impurity 15 (CAS 636-73-7)
- Vonoprazan Impurity 153 (CAS 15103-48-7)
- Vonoprazan Impurity 154 (CAS 5402-20-0)
- Vonoprazan Impurity 36 (CAS 56448-22-7)
- Vonoprazan Fumarate Impurity 74 (CAS 4847-34-1)
- Vonoprazan Fumarate Impurity 22 (CAS 1934459-20-7)
- Vonoprazan Impurity 188 (CAS 111480-82-1)
Recommended Standards
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- 4-Bromobut-2-enamide (CAS 118941-93-8)
- 5-Amino-2,4-dichloropyrimidine (CAS 5177-27-5)
- 1-Azido-3-bromopropane (CAS 153732-56-0)
- Sunitinib Impurity 75 (CAS 342642-56-2)
- Sugammadex Impurity 83 (CAS 2412952-90-8)
- Upadacitinib Impurity 146 (CAS CATO-C4X-2405146)
- Glycyl-DL-phenylalanine (CAS 721-66-4)
- Pioglitazone impurity 27 (CAS CATO-C4X-138327)
- 2-{[4-(methylsulfanyl)phenoxy]methyl}oxirane (CAS 1343235-66-4)
- 3,4-Dimethoxypyrrolidine hydrochloride (CAS 1622351-30-7)
- 7-Chloro-3,4-dihydroquinoxalin-2(1H)-one (CAS 66367-05-3)
- 2-Bromophenyl propionate (CAS 23600-76-2)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
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