Imatinib Impurity 51 CAS 152460-08-7
| CAS No. | 152460-08-7 |
| Molecular Formula | C8H10N4O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Imatinib Impurity 51 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Imatinib Impurity 51 (CAS 152460-08-7) is a certified pharmaceutical impurity reference standard with the molecular formula C8H10N4O2NO3 and a molecular weight of 256.20 g/mol.
The molecular framework of Imatinib Impurity 51 (C8H10N4O2NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C8H10N4O2 NO3 |
| Molecular Weight | 256.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Nitrogen Atoms | 5 |
Related Imatinib Standards
- Imatinib Impurity 10 (CAS 1026753-54-7)
- 6-Methyl Imatinib (CAS 1032314-85-4)
- Imatinib Impurity 17 (CAS 106261-49-8)
- Imatinib Impurity 48 (CAS 106261-64-7)
- Imatinib-d8 (CAS 1092942-82-9)
- Imatinib Impurity 18 (CAS 112696-91-0)
- Imatinib Impurity 48 (CAS 1131605-15-6)
- Imatinib-d3 (N-methyl-d3) (CAS 1134803-18-1)
Recommended Standards
- Erlotinib Impurity 113 (CAS 587-02-0)
- Losartan Impurity 52 (CAS CATO-C4X-168352)
- Cinnarizine EP Impurity D (CAS 1199751-98-8)
- WAY 267464 Dihydrochloride (CAS 847375-16-0)
- (4,8-Bis(5-(2-ethylhexyl)-4-hexylthiophen-2-yl)benzo[1,2-b:4,5-b']dithiophene-2,6-diyl)bis(trimethylstannane) (CAS 1627681-05-3)
- Ethyl 4-(2-((3-methyl-4-oxo-7-(p-tolyl)-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)acetamido)benzoate (CAS 1040631-84-2)
- 6-(1-Amino-2-methylpropyl)-2,3-dihydro-1,3-benzoxazol-2-one hydrochloride (CAS 1311315-61-3)
- 2-(2-Propylbenzofuran-3-yl)acetonitrile (CAS 37681-05-3)
- N,N-dimethyltetradecan-1-amine (CAS 112-75-4)
- Peptide Impurity 26 (CAS 1350456-66-4)
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