Cladribine Impurity N77 CAS 152463-97-3
| CAS No. | 152463-97-3 |
| Molecular Formula | C18H18ClN5O4 |
| Molecular Weight | 403.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Cladribine Impurity N77 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Cladribine Impurity N77 (CAS 152463-97-3), a pharmacopoeial impurity reference standard (molecular formula C18H18ClN5O4, MW 403.82 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Cladribine Impurity N77 (C18H18ClN5O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Cladribine Impurity N77 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H18ClN5O4 |
| Molecular Weight | 403.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Cladribine Standards
- Cladribine Impurity N78 (CAS 152463-98-4)
- Cladribine EP Impurity D (CAS 5542-92-7)
- Cladribine (CAS 4291-63-8)
- Cladribine EP Impurity B (CAS 24757-70-8)
- Cladribine EP Impurity A (CAS 4546-70-7)
- Cladribine EP Impurity C (CAS 1839-18-5)
- Cladribine EP Impurity G (CAS 99-75-2)
- Cladribine Impurity 2 (CAS 533-67-5)
Recommended Standards
- 1,1,1,3,7,9,9,9-Octachlorononane (CAS 13389-26-9)
- Ochratoxin A (CAS 303-47-9)
- N-(9-Chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)-2-phenylacetamide (CAS 183721-15-5)
- Lansoprazole Impurity 60 (CAS CATO-C4X-111360)
- Vonoprazan Impurity 192(Mixture of Z and E Isomers) (CAS CATO-C4X-1020192)
- Ilaprazole Impurity 26 (CAS 2285346-41-8)
- Entacapone impurity 51 (CAS CATO-C4X-162951)
- (2-Bromo-5-methyl-oxazol-4-yl)-methanol (CAS 1240612-18-3)
- 3-(4-Oxo-1,2,3-benzotriazin-3(4H)-yl)propanoic acid (CAS 51672-79-8)
- Methyl 4,5-Dihydro-4-(2-methoxy-2-oxoethyl)-2-methyl-5-oxo-1h-pyrrole-3-carboxylate (CAS 1823184-06-0)
- Methyl 4-bromo-3-methylisoxazole-5-carboxylate (CAS 1092301-44-4)
- tert-Butyl 2-((2,4-difluorophenyl)amino)acetate (CAS 1179163-46-2)
- Ethyl 2-(ethylamino)-4-methyl-1,3-thiazole-5-carboxylate (CAS 4280-80-2)
- [2-31]-Semaglutide C (x TFA Salt) (CAS CATO-C4X-2226118)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com