8-(Difluoromethoxy)-1-ethyl-6-fluoro-7-(4-(2-methoxyphenyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid CAS 153468-00-9
| CAS No. | 153468-00-9 |
| Molecular Formula | C24H24F3N3O5 |
| Molecular Weight | 491.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 8-(Difluoromethoxy)-1-ethyl-6-fluoro-7-(4-(2-methoxyphenyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 8-(Difluoromethoxy)-1-ethyl-6-fluoro-7-(4-(2-methoxyphenyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 153468-00-9), a certified reference material (molecular formula C24H24F3N3O5, MW 491.46 g/mol) for analytical method development and quality control.
8-(Difluoromethoxy)-1-ethyl-6-fluoro-7-(4-(2-methoxyphenyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (C24H24F3N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 8-(Difluoromethoxy)-1-ethyl-6-fluoro-7-(4-(2-methoxyphenyl)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H24F3N3O5 |
| Molecular Weight | 491.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Difluoromethoxy Standards
- 1,4-Bis((4-(difluoromethoxy)phenyl)amino)anthracene-9,10-dione (CAS 62149-29-5)
- (2-((4-(Difluoromethoxy)phenyl)amino)thiazol-4-yl)(4-(pyrimidin-2-yl)piperazin-1-yl)methanone (CAS 1105220-22-1)
- Methyl 6-(4-(difluoromethoxy)phenyl)-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011400-18-2)
- 3-(4-(Difluoromethoxy)phenyl)-1-(furan-2-yl)-3-(quinolin-8-ylthio)propan-1-one (CAS 325474-43-9)
- N-(4-(Difluoromethoxy)-3-methoxybenzyl)-2-(1,3-dioxoisoindolin-2-yl)-N-methylpropanamide (CAS 865278-12-2)
- 1-((2-(4-(Difluoromethoxy)Phenyl)-2-Methylpropoxy)Methyl)-3-(4-Fluorophenoxy)Benzene (CAS 80843-63-6)
- N-(4-(5-(Difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide (CAS 245747-71-1)
- 1-[2-(Difluoromethoxy)benzyl]-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole (CAS 1515924-46-5)
Recommended Standards
- Zidovudine EP Impurity G (CAS 148665-49-0)
- (9S)-N-[3-(1,3-Oxazol-5-yl)phenyl]-5-[3-(trifluoromethyl)phenyl]-1,6,8-triazatricyclo[7.2.1.0,2,7]dodeca-2,4,6-triene-8-carboxamide (CAS 1638597-29-1)
- Dapagliflozin Impurity 24 (CAS 2176485-21-3)
- 2-[2-[2-(2-t-Boc-aminoethoxy]ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzoic Acid Methyl Ester (CAS 165963-73-5)
- Ethyl 3-Methyl-3-Phenylglycidate (CAS 77-83-8)
- N-(2-hydrazinyl-1-(4-hydroxyphthalazin-1-yl)-2-oxoethyl)benzamide (CAS 49660-30-2)
- 2-Cyano-3-(1H-indol-3-yl)propanamide (CAS 860360-25-4)
- 1-(3,4-Dimethoxyphenyl)-5-oxo-3-pyrrolidinecarboxylic acid (CAS 39629-91-9)
- 1-(4,6-Dimethylpyrimidin-2-yl)-3-(3-(trifluoromethyl)phenyl)guanidine (CAS 94828-52-1)
- 4-Chloro-N-((5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methyl)aniline (CAS 956186-49-5)
- 2-(2,4-Dimethylphenyl)indoline Oxalate (CAS 1177308-47-2)
- 4-Bromo-N-(4-(cyanomethoxy)phenyl)-1H-pyrrole-2-carboxamide (CAS 1308340-26-2)
- 2-(3-Methoxyphenyl)-6,7-dihydro-1H-[1,4]dioxino[2',3':4,5]benzo[1,2-d]imidazole (CAS 1097798-92-9)
- Bonemarrow-Derived Mesenchymal Stem Cells Affinity Peptide trifluoroacetate salt (CAS 683750-83-6)
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