Betahistine impurity 02 HCl CAS 15430-49-6
| CAS No. | 15430-49-6 |
| Molecular Formula | C8H12N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Betahistine impurity 02 HCl is closely related to a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Betahistine impurity 02 HCl (CAS 15430-49-6, C8H12N2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H12N2HCl, Betahistine impurity 02 HCl contains a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 172.66 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H12N2 HCl |
| Molecular Weight | 172.66 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Betahistine Standards
- Betahistine EP Impurity A (CAS 100-69-6)
- Betahistine Impurity 01 DiHCl (CAS 101252-40-8)
- Betahistine EP Impurity B (CAS 103-74-2)
- Betahistine Impurity 12 (CAS 109-06-8)
- Betahistine impurity 41 (CAS 113985-59-4)
- Betahistine Impurity 45 (CAS 128225-22-9)
- Betahistine impurity 33 (CAS 13585-92-7)
- Betahistine Impurity 13 HCl (CAS 13585-92-7（free base）)
Recommended Standards
- Phentolamine Impurity 23 (CAS CATO-C4X-224723)
- Procaterol Impurity 21 (CAS CATO-C4X-181021)
- Mirogabalin Impurity 160 (CAS CATO-C4X-2924160)
- n-(2-Methoxyethyl)-4-phenylthiazol-2-amine (CAS 484693-73-4)
- (R)-1-(5-Methoxy-2-pyridyl)ethanamine (CAS 953780-25-1)
- 1-(2-Bromo-4-fluorophenyl)cyclopropanecarboxylic Acid (CAS 1314779-98-0)
- 1-(Azetidin-3-yl)-N,N-dimethyl-5-oxopyrrolidine-3-carboxamide hydrochloride (CAS 2138194-41-7)
- 3-(Aminomethyl)-2-fluorobenzoic acid (CAS 1534353-00-8)
- N-(2-Chlorobenzyl)-2-(2,4-dichlorophenoxy)-1-propanamine (CAS 1040684-13-6)
- Rac1 Inhibitor F56, control peptide (CAS 1315378-77-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com