Voriconazole Impurity 43 CAS 154335-57-6
| CAS No. | 154335-57-6 |
| Molecular Formula | C12H20O4S |
| Molecular Weight | 260.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Voriconazole Impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Voriconazole Impurity 43 (CAS 154335-57-6, C12H20O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H20O4S, Voriconazole Impurity 43 contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 260.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H20O4S |
| Molecular Weight | 260.35 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2001 |
| Sulfur Atoms | 1 |
Related Voriconazole Standards
- Voriconazole Impurity 7 (CAS CATO-C4X-13667)
- Voriconazole Impurity 82 (CAS CATO-C4X-136682)
- Voriconazole Impurity 8 (CAS 83603-04-7)
- Voriconazole Impurity 3 (CAS 188416-28-6)
- Voriconazole Impurity 72 (CAS CATO-C4X-136672)
- Voriconazole Impurity 28 (CAS 1307315-02-1)
- Voriconazole Impurity 66 (CAS CATO-C4X-136666)
- Voriconazole Impurity 86 (CAS CATO-C4X-136686)
Recommended Standards
- (ethylsulfonyl-phenyl-methyl)benzene (CAS 6974-50-1)
- tert-Butyl 2-iminohexahydro-2λ4-thieno[3,4-c]pyrrole-5(1H)-carboxylate 2-oxide (CAS 2892449-68-0)
- Camphor Sulfonic Acid Ethyl Ester (CAS CATO-C4X-21141)
- Tert-butyl (4-(aminomethyl)-4-(fluoromethyl)cyclohexyl)carbamate (CAS 2387596-00-9)
- Formoterol Impurity 62 (CAS CATO-C4X-152562)
- Landiolol Impurity 122 (CAS CATO-C4X-2621122)
- Morinidazole Impurity 22 (CAS CATO-C4X-219622)
- 3-[(3-Chloro-4-methylphenyl)amino]-cyclohex-2-en-1-one (CAS 1217862-35-5)
- 3-(Pyrazin-2-ylamino)cyclohexane-1-carboxylic acid (CAS 1341373-13-4)
- tert-butyl N-(7-methyl-5-azaspiro[2.4]heptan-7-yl)carbamate (CAS 915795-05-0)
- 2-Cyclohexyl-5,6,7,8-tetrahydroquinazolin-4(1H)-one (CAS 105550-66-1)
- Methyl 6-amino-4-methylpyridine-3-carboxylate (CAS 179555-12-5)
- 2-(Tert-butylsulfonyl)acetonitrile (CAS 81536-18-7)
- Peptide Impurity 27 (CAS 1350456-68-6)
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