Voriconazole Impurity 3 CAS 188416-28-6
| CAS No. | 188416-28-6 |
| Molecular Formula | C6H5BrClFN2 |
| Molecular Weight | 239.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Voriconazole Impurity 3.
CATO supplies Voriconazole Impurity 3 (CAS 188416-28-6), a pharmacopoeial impurity reference standard (molecular formula C6H5BrClFN2, MW 239.47 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Voriconazole Impurity 3 (C6H5BrClFN2) is characterized by a nitrile group, fluorine/chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Voriconazole Impurity 3 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H5BrClFN2 |
| Molecular Weight | 239.47 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Voriconazole Standards
- Voriconazole Impurity 72 (CAS CATO-C4X-136672)
- Voriconazole Impurity 86 (CAS CATO-C4X-136686)
- Voriconazole Impurity 8 (CAS 83603-04-7)
- Voriconazole EP Impurity E(Voriconazole Related Compound F) (CAS 5872-08-2)
- Voriconazole EP Impurity E (1R)-Isomer (CAS 35963-20-3)
- Voriconazole Impurity N2 (CAS 168479-96-7)
- Voriconazole Impurity 31 (CAS 1157981-64-0)
- Voriconazole Impurity 33 (CAS 1449785-88-9)
Recommended Standards
- 5-Bromo-3-chloro-4-fluorobenzene-1,2-diamine (CAS 2728217-75-0)
- 1-(2,3,5-Trichloro-6-hydroxyphenyl)ethan-1-one (CAS 101580-94-3)
- 5-bromo-1-chloro-3-fluoro-2-methoxybenzene (CAS 261762-34-9)
- 3,6-Dichloro-2-methoxybenzoyl chloride (CAS 10411-85-5)
- Isavuconazole Impurity 6 (CAS CATO-C4X-12366)
- Axitinib Impurity 26 (CAS CATO-C4X-107126)
- Cefixime EP Impurity C (CAS 108691-83-4)
- (5-phenoxypyridin-2-yl)methanamine dihydrochloride (CAS 1955531-07-3)
- 2-[4-(dimethylcarbamoyl)-1h-1,2,3-triazol-1-yl]acetic acid (CAS 1505149-43-8)
- 3-(3-Hydroxyprop-1-en-1-yl)benzonitrile (CAS 98116-50-8)
- 4-Chloro-5-((3-chlorobenzyl)oxy)-2-methylpyridazin-3(2H)-one (CAS 88121-78-2)
- 1040688-93-4 3-(Benzyloxy)-N-{2-[2-(sec-butyl)phenoxy]-propyl}aniline (CAS 1040688-93-4)
- 1-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)-3-(3-phenoxyphenyl)thiourea (CAS 326815-18-3)
- Peptide Impurity 06 (CAS CATO-CPTD788806)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com