Octreotide EP Impurity E CAS 1546983-27-0(Free base)
| CAS No. | 1546983-27-0(Free base) |
| Molecular Formula | C49H66N10O10S3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Octreotide EP Impurity E (CAS 1546983-27-0(Free base)), a pharmacopoeial impurity reference standard (molecular formula C49H66N10O10S3C2HF3O2, MW 1165.33 g/mol) used for the identification and quantification of trace impurities in APIs.
Octreotide EP Impurity E (C49H66N10O10S3C2HF3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C49H66N10O10S3 C2HF3O2 |
| Molecular Weight | 1165.33 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 22.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 10 |
| Sulfur Atoms | 3 |
Related Octreotide Standards
- Octreotide EP Impurity G Acetate (CAS 108102-47-2（free base）)
- Octreotide-D8 Acetate (CAS 1240797-41-4)
- Octreotide EP Impurity F (CAS 133304-81-1（free base）)
- Octreotide EP Impurity C (CAS 1546983-16-7)
- Octreotide EP Impurity H Acetate (CAS 173606-11-6)
- Octreotide trifluoroacetate salt (Dimer, Antiparallel) (CAS 1926163-78-1)
- Octreotide trifluoroacetate salt (Dimer, Parallel) (CAS 1926163-80-5)
- Octreotide (CAS 79517-01-4)
Recommended Standards
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- 3-(Allyloxy)-7-methylbenzofuran-2-carboxylic acid (CAS 1707609-63-9)
- 4-Bromo-2-chloro-1-cyclopropoxybenzene (CAS 869569-68-6)
- 9-Fluoro-5,6-dihydrobenzo[c]acridine-7-carboxylic acid (CAS 1536-29-4)
- tert-Butyl 4-(2-aminoethyl)-4-phenyl-1-piperidinecarboxylate (CAS 1211583-32-2)
- 5-(1-Methyl-1H-pyrrol-2-yl)-3-(pyrrolidin-2-yl)-1,2,4-oxadiazole (CAS 1708079-83-7)
- 2-(2,6-Dimethylphenyl)-1,3-dioxoisoindoline-5-carboxylic acid (CAS 110768-27-9)
- Fibrinogen-Binding Peptide (CAS 137235-80-4)
Why CATO?
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