Tofacitinib Impurity 164 CAS 71607-31-3
| CAS No. | 71607-31-3 |
| Molecular Formula | C20H18O8 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Tofacitinib Impurity 164 (CAS 71607-31-3, C20H18O8H2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, a hydroxyl group, an ether linkage, Tofacitinib Impurity 164 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 404.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H18O8 H2O |
| Molecular Weight | 404.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
Related Tofacitinib Standards
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 133 (CAS 10132-07-7)
- Tofacitinib Impurity 182 (CAS 1053228-28-6)
- Tofacitinib Impurity 123 DiHCl (CAS 1062580-52-2)
- Tofacitinib Impurity 20 (CAS 1092578-43-2)
- Tofacitinib Impurity 38 (CAS 1092578-45-4)
- Tofacitinib Impurity 1 (CAS 1092578-46-5)
- Tofacitinib Impurity 3 (CAS 1092578-47-6)
Recommended Standards
- Vonoprazan Impuirty 144 (CAS 13069-02-8)
- Atrasentan Impurity 152 (CAS 1058404-01-5)
- Amlodipine Impurity 147 (CAS CATO-C4X-1095147)
- Methyl 2-(((4-isopropylphenoxy)carbonyl)amino)benzoate (CAS 866153-47-1)
- 6,6-Difluoro-2-azaspiro[3.3]heptane Trifluoroacetate (CAS 1354952-05-8)
- 3-(4-Boc-1-piperazinyl)aniline (CAS 206879-72-3)
- (2S,3S)-3-fluoro-2-methyl-azetidine;hydrochloride (CAS 2231664-75-6)
- 2-(3-Cyclopropyl-1H-pyrazol-1-yl)ethan-1-amine dihydrochloride (CAS 2138111-29-0)
- 1,4-Benzenedicarboxylic acid, polymer with 12-aminododecanoic acid and 1,4-butanediol (CAS 73002-55-8)
- Steroidogenesis-Activator Polypeptide (rat) (H-8855.0500) (CAS 108563-23-1)
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