Phenacetin Impurity 10 CAS 15596-57-3
| CAS No. | 15596-57-3 |
| Molecular Formula | C12H10N2O3 |
| Molecular Weight | 230.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Phenacetin Impurity 10 (C12H10N2O3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Phenacetin Impurity 10 (CAS 15596-57-3, C12H10N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10N2O3 |
| Molecular Weight | 230.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 2 |
Related Phenacetin Standards
- Phenacetin Impurity 7 (CAS 60457-49-0)
- Phenacetin Impurity 8 (CAS 7466-38-8)
- Phenacetin Impurity N2 (CAS 2050-16-0)
- Phenacetin Impurity 4 (CAS 53689-25-1)
- Phenacetin Impurity N1 (CAS 21650-51-1)
- Phenacetin Impurity 16 (CAS 30926-04-6)
- Phenacetin Impurity 5 (CAS 102236-24-8)
- Phenacetin Impurity 8 (CAS 188905-67-1)
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- 4-Aminopiperidine-2,2,3,3,4,5,5,6,6-d<SUB>9</SUB> (CAS 1173020-92-2)
- Insulin Degludec Impurity 17 (CAS CATO-C4X-215717)
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