Phenacetin Impurity 4 CAS 53689-25-1
| CAS No. | 53689-25-1 |
| Molecular Formula | C10H12ClNO2 |
| Molecular Weight | 213.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Phenacetin Impurity 4 (CAS 53689-25-1) is a certified pharmaceutical impurity reference standard with the molecular formula C10H12ClNO2 and a molecular weight of 213.66 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Phenacetin Impurity 4 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 213.66 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Phenacetin Impurity 4 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H12ClNO2 |
| Molecular Weight | 213.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Phenacetin Standards
Recommended Standards
- Proparacaine Impurity 19 (CAS 343773-15-9)
- Lifitegrast Impurity 149 (CAS CATO-C4X-2409149)
- Lidocaine impurity 64 (CAS 64585-19-9)
- Procaine Impurity 8 (CAS 59265-81-5)
- Netupitant Impurity 50 (CAS CATO-C4X-122350)
- Fluticasone Impurity 49 (CAS CATO-C4X-165049)
- Pioglitazone Impurity 2 (CAS CATO-C4X-13832)
- (2-Bromo-5-methoxyphenyl)(7-phenyl-1,4-thiazepan-4-yl)methanone (CAS 1797190-71-6)
- 5-Ethyl-2-hydroxypyridine (CAS 53428-03-8)
- 5-Bromo-2-(cyclopropylmethoxy)pyridine (CAS 494772-02-0)
- 1-(3,5-Dichlorophenyl)-N-methyl-2-(pyrrolidin-1-yl)ethanamine (CAS 672310-02-0)
- 2-Amino-9-propyl-1H-purin-6(9H)-one (CAS 22917-85-7)
- 2-((4-((Cyclopropylmethyl)amino)cyclohexyl)amino)acetic acid (CAS 1353958-83-4)
- Semaglutide Impurity 162 (x TFA Salt) (CAS CATO-C4X-2226162)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com