Atazanavir Impurity 11 CAS 156474-22-5
| CAS No. | 156474-22-5 |
| Molecular Formula | C15H21NO3 |
| Molecular Weight | 263.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Atazanavir Impurity 11 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Atazanavir Impurity 11 (CAS 156474-22-5, C15H21NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Atazanavir Impurity 11 (C15H21NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 263.33 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Atazanavir Impurity 11 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H21NO3 |
| Molecular Weight | 263.33 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Nitrogen Atoms | 1 |
Related Atazanavir Standards
- Atazanavir Impurity N1 (Relative stereochemistry) (CAS 98818-34-9)
- Atazanavir Impurity 10 (CAS 98737-29-2)
- Atazanavir Impurity 13 (CAS 98760-08-8)
- Atazanavir impurity 19 (CAS 156474-21-4)
- Atazanavir Impurity 23 (CAS 149451-80-9)
- Atazanavir Impurity 12 (CAS 198904-84-6)
- Atazanavir Impurity 14 (CAS 102123-74-0)
- Atazanavir Impurity 12 (CAS 162536-40-5)
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