Rupatadine impurity 6 CAS 156523-04-5
| CAS No. | 156523-04-5 |
| Molecular Formula | C26H24ClN3O |
| Molecular Weight | 429.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Rupatadine impurity 6 (CAS 156523-04-5), a pharmacopoeial impurity reference standard (molecular formula C26H24ClN3O, MW 429.94 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Rupatadine impurity 6 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 429.94 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C26H24ClN3O |
| Molecular Weight | 429.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Rupatadine Standards
- Rupatadine Impurity 38 (CAS CATO-C4X-102738)
- Rupatadine Impurity 42 (CAS CATO-C4X-102742)
- Rupatadine Impurity 16 (CAS CATO-C4X-102716)
- Rupatadine impurity 17 (CAS CATO-C4X-102717)
- Rupatadine impurity 7 (CAS 1704730-21-1)
- Rupatadine impurity 8 (CAS CATO-C4X-10278)
- Rupatadine impurity 12 (CAS CATO-C4X-102712)
- Rupatadine Impurity 26 (CAS CATO-C4X-102726)
Recommended Standards
- (1S,3R)-3-acetamido-N-[5-chloro-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide (CAS 2057509-72-3)
- 4-chlorophenyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)-4-phenyl-1,3-thiazol-5-yl sulfone 955976-35-9 KS-000038GL (CAS 955976-35-9)
- 2-(4-tert-Butylphenoxy)-3-(4-chlorobenzenesulfonyl)-4,6-dimethylpyridine (CAS 478245-25-9)
- Tert-butyl 4-(4-((4-chlorobenzamido)methyl)phenyl)piperazine-1-carboxylate (CAS 866018-62-4)
- Orphenadrine Impurity 2 (CAS CATO-C4X-33172)
- Alprazolam EP Impurity E (CAS 719-59-5)
- Etrasimod Impurity 75 (CAS CATO-C4X-321475)
- 3-[(1-Benzylpiperidin-4-yl)amino]pyrrolidine-2,5-dione (CAS 1218642-40-0)
- Gefitinib Impurity 42 (CAS CATO-C4X-111742)
- H-Arg(NO2)-OBzl p-tosylate salt (CAS 7672-27-7)
- D-Glucal (CAS 26566-29-0)
- 2-Cyclopropyl-6-methylpyrimidin-4-ol (CAS 7043-10-9)
- 1-(1-Bromoethyl)-4-cyclohexylbenzene (CAS 65189-98-2)
- Neuropeptide Y (1-24) amide (human, rat) (CAS 131448-51-6)
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