Alprazolam EP Impurity E CAS 719-59-5
| CAS No. | 719-59-5 |
| Molecular Formula | C13H10ClNO |
| Molecular Weight | 231.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Alprazolam EP Impurity E (CAS 719-59-5, C13H10ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Alprazolam EP Impurity E is typically pale yellow to yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 231.68 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H10ClNO |
| Molecular Weight | 231.68 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Alprazolam Standards
- Alprazolam Impurity 5 (CAS 5220-83-7)
- Alprazolam Impurity 4 (CAS 27610-14-6)
- Alprazolam Impurity 7 (CAS 1346606-48-1)
- Alprazolam Impurity 15 (CAS 963-39-3)
- Alprazolam EP Impurity A (CAS 27537-87-7)
- Alprazolam EP Impurity C (CAS 36916-19-5)
- Alprazolam Impurity 2 (CAS 4016-85-7)
- Alprazolam impurity 24 (CAS CATO-C4X-146024)
Recommended Standards
- Temozolomide Impurity 25 (CAS 83-01-2)
- Urapidil Impurity 3 (CAS 34654-81-4)
- Ezetimibe Impurity 50 (CAS 3369-35-5)
- Urapidil Impurity 48 (CAS CATO-C4X-192448)
- Paricalcitol Impurity 38 (CAS CATO-C4X-138738)
- Piribedil Impurity 2 (CAS CATO-C4X-28132)
- Nicardipine Impurity 47 (CAS 54527-65-0)
- Diethyl Oxalate-13C2 (CAS 150992-84-0)
- D-Citronellol (CAS 1117-61-9)
- Cefdinir CP Impurity D (CAS 934986-48-8)
- N-(adamantan-2-yl)-2-(naphthalen-2-yloxy)acetamide (CAS 425374-30-7)
- Levothyroxine Impurity 4 (CAS 910907-23-2)
- 4-Hydrazinyl-2-(trifluoromethyl)quinoline (CAS 1828-97-3)
- C-Peptide 1 (rat) (CAS 41475-27-8)
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