Bosentan impurity 16 CAS 157415-45-7
| CAS No. | 157415-45-7 |
| Molecular Formula | C27H29N5O5S |
| Molecular Weight | 535.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Bosentan impurity 16 (CAS 157415-45-7, C27H29N5O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Bosentan impurity 16 (C27H29N5O5S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 535.61 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Bosentan impurity 16 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C27H29N5O5S |
| Molecular Weight | 535.61 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Bosentan Standards
- Bosentan USP Related Compound A (CAS 150727-06-3)
- Bosentan (CAS 147536-97-8)
- Bosentan-D4 (CAS 1065472-77-6)
- Bosentan USP Related Compound B (CAS 174227-14-6)
- Bosentan Hydroxy (CAS 253688-60-7)
- Bosentan Impurity 02 (CAS 301646-61-7)
- Bosentan Impurity 15 (CAS 1257099-43-6)
- Bosentan Impurity 12 (CAS CATO-C4X-156412)
Recommended Standards
- [(1S,2R)-3-[[(4-Nitrophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-phenylmethyl)propyl]carbamic Acid, (3S)-Tetrahydro-3-furanyl Ester (CAS 160231-69-6)
- 3’,5’-Bis-O-(tert-butyldimethylsilyl)-5-bromo-2’-deoxyuridine (CAS 154925-95-8)
- 4'-Demethyl Homoharringtonine-13C,d3 (CAS 1217669-36-7)
- 536755-34-7 Bis(2-methyl-dibenzo[f,h]quinoxaline)(acetylacetonate)iridium (III) Ir(2-phq)2(acac) (CAS 536755-34-7)
- Vericiguat Impurity 61 (CAS CATO-C4X-289661)
- Tamsulosin EP Impurity C (CAS 2244986-82-9)
- Dalilesen Impurity 9 (CAS CATO-C4X-30109)
- Tert-butyl (2-methyl-1-oxo-1-(piperazin-1-yl)propan-2-yl)carbamate (CAS 1303890-06-3)
- Vonoprazan Impurity 209 (CAS 31543-47-2)
- 5-Bromo-N-cyclohexyl-4-methyl-2-pyridinamine (CAS 1220035-72-2)
- 2-Cyclohexyl-3,4-dihydroisoquinolin-1(2H)-one (CAS 6772-63-0)
- 2-Bromo-1-(naphthalen-2-yl)pentan-1-one (CAS 850352-43-1)
- (4-(n-Butylsulfamoyl)phenyl)boronic acid (CAS 850589-32-1)
- Des-Gln19-Tirzepatide (CAS CATO-CPTD788954)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com