Ethyl 5-(difluoromethyl)thiophene-2-carboxylate CAS 1575820-69-7
| CAS No. | 1575820-69-7 |
| Molecular Formula | C8H8F2O2S |
| Molecular Weight | 206.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Ethyl 5-(difluoromethyl)thiophene-2-carboxylate (CAS 1575820-69-7), a certified reference material (molecular formula C8H8F2O2S, MW 206.21 g/mol) for analytical method development and quality control.
Ethyl 5-(difluoromethyl)thiophene-2-carboxylate (C8H8F2O2S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H8F2O2S |
| Molecular Weight | 206.21 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Ethyl Standards
- Ethyl 5-(difluoromethyl)thiophene-3-carboxylate (CAS 189331-48-4)
- 1-((Difluoromethyl)sulfonyl)-4-methylbenzene (CAS 4837-17-6)
- Difluoromethyl 3-methylphenyl sulphone (CAS 4837-16-5)
- 2-(Difluoromethyl)naphthalene-7-carboxaldehyde (CAS 1261661-02-2)
- 1-(Difluoromethyl)naphthalene-4-carboxaldehyde (CAS 1261871-64-0)
- 2-(Difluoromethyl)naphthalene-3-carboxaldehyde (CAS 1261871-66-2)
- 4-(Difluoromethyl)-2-phenylpyrimidine (CAS 1261885-09-9)
- 1-(Difluoromethyl)naphthalene-3-carboxaldehyde (CAS 1261885-69-1)
Recommended Standards
- 1-Fluoro-4-(2-fluoroethanesulfonyl)benzene (CAS 1506533-24-9)
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- 3-(3-fluoro-4-methoxyphenyl)cyclopent-2-en-1-one (CAS 1499305-24-6)
- 5'-Fluoro-2',3'-dihydrospiro[cyclopropane-1,1'-indene]-2-carboxylic acid (CAS 1600862-20-1)
- Ethyl 3-amino-3-(naphthalen-1-yl)propanoate hydrochloride (CAS 252354-06-6)
- (S)-tert-Butyl 5-((tert-butoxycarbonyl)amino)-3-oxohexanoate (CAS 2762829-44-5)
- CAS 2172819-73-5 (CAS 2172819-73-5)
- 2'-O-(tert-Butyldimethylsilyl)-3'-deoxy-5'-O-trityluridine (CAS 130860-12-7)
- (E)-N-(2,4-dimethoxyphenyl)-3-(4-(trifluoromethoxy)phenyl)acrylamide (CAS 882082-42-0)
- 4-Bromo-2-methoxy-5-nitrobenzonitrile (CAS 2351149-59-0)
- 2-(3-(2-(dimethylamino)ethoxy)-4-hydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one hydrochloride (CAS CATO-C3D-262411)
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