Lumateperone Impurity 2 CAS 1576240-15-7
| CAS No. | 1576240-15-7 |
| Molecular Formula | C24H28FN3O |
| Molecular Weight | 393.50 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Lumateperone Impurity 2 (CAS 1576240-15-7, C24H28FN3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lumateperone Impurity 2 (C24H28FN3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H28FN3O |
| Molecular Weight | 393.50 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Lumateperone Standards
- Lumateperone (CAS 313368-91-1)
- Lumateperone Impurity 1 (CAS 313368-92-2)
- Lumateperone Impurity 3 (CAS CATO-C4X-22013)
- Lumateperone Impurity 56 (CAS CATO-C4X-220156)
- Lumateperone Impurity 72 (CAS CATO-C4X-220172)
- Lumateperone Impurity 33 (CAS 2117618-96-7)
- Lumateperone Impurity 50 (CAS 2117618-98-9)
- Lumateperone Impurity 18 (CAS 1469343-42-7)
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