Azacitidine Impurity 3 CAS 157771-77-2
| CAS No. | 157771-77-2 |
| Molecular Formula | C8H12N4O5 |
| Molecular Weight | 244.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Azacitidine Impurity 3.
CATO supplies Azacitidine Impurity 3 (CAS 157771-77-2), a pharmacopoeial impurity reference standard (molecular formula C8H12N4O5, MW 244.20 g/mol) used for the identification and quantification of trace impurities in APIs.
Azacitidine Impurity 3 (C8H12N4O5) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Azacitidine Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12N4O5 |
| Molecular Weight | 244.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Nitrogen Atoms | 4 |
Related Azacitidine Standards
- Azacitidine Impurity 14 (CAS 206269-46-7)
- Azacitidine (CAS 320-67-2)
- Azacitidine Impurity 27 (CAS 65886-71-7)
- Azacitidine Impurity 45 (CAS CATO-C4X-138845)
- Azacitidine Impurity 28 (CAS 3530-56-1)
- Azacitidine Impurity 29 (CAS 26524-60-7)
- Azacitidine Impurity 43 (CAS 13913-16-1)
- Azacitidine Impurity 52 (CAS 77172-20-4)
Recommended Standards
- Ribavirin EP Impurity B (CAS 57198-02-4)
- Nicotinic Acid EP Impurity B (CAS 1802-30-8)
- Ribavirin EP Impurity G (CAS 39030-43-8)
- 1-(a-D-ribofuranosyl)uracil (CAS 3258-07-9)
- Clemastine Impurity 33 (CAS CATO-C4X-183733)
- Apixaban Impurity 61 (CAS CATO-C4X-108861)
- Nintedanib Impurity 87 (CAS CATO-C4X-181487)
- 1-Palmitoyl-2-[3-(diphenylhexatriene)propanoyl]-sn-phosphatidylcholine (CAS 98014-38-1)
- 1-Aminonaphthalene-3-carboxylic acid ethyl ester (CAS 54143-46-3)
- Cyclobutyl(o-tolyl)methanamine (CAS 1337165-71-5)
- N-(4-bromobenzyl)hexan-2-amine (CAS 1249585-88-3)
- 1,3,5,7,9,11,13,15-Octacyclohexyl-2,4,6,8,10,12,14,16,17,18,19,20-dodecaoxa-1,3,5,7,9,11,13,15-octasilapentacyclo[9.5.1.13,9.15,15.17,13]icosane (CAS 3809-28-7)
- N,N-Dimethylbenzo[d]thiazol-5-amine (CAS 861780-63-4)
- Tau Peptide (298-312) trifluoroacetate salt (CAS 330456-47-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com