Tolvaptan Impurity 31 CAS 1580889-21-9
| CAS No. | 1580889-21-9 |
| Molecular Formula | C18H16ClNO2 |
| Molecular Weight | 313.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Tolvaptan Impurity 31 (CAS 1580889-21-9, C18H16ClNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tolvaptan Impurity 31 (C18H16ClNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H16ClNO2 |
| Molecular Weight | 313.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Tolvaptan Standards
- Tolvaptan Impurity 128 (CAS CATO-C4X-1955128)
- Tolvaptan Impurity 27 (CAS 1859917-22-8)
- Tolvaptan impurity 114 (CAS CATO-C4X-1955114)
- Tolvaptan Impurity 92 (CAS 1580889-22-0)
- Tolvaptan Impurity 48 (CAS 897-82-5)
- Tolvaptan Impurity 3 (CAS CATO-C4X-19553)
- Tolvaptan Impurity 11 (CAS 137977-97-0)
- Tolvaptan Impurity 55 (CAS 1401998-56-8)
Recommended Standards
- Metoclopramide impurity 59 (CAS CATO-C4X-141559)
- Arimoclomol (CAS 289893-25-0)
- Metoclopramide impurity 58 (CAS CATO-C4X-141558)
- Pyronaridine Impurity 7 (CAS CATO-C4X-29787)
- Cefdinir Impurity 42 (CAS CATO-C4X-121042)
- Tafamidis Impurity 6 (CAS 1507158-86-2)
- N-Nitroso Telmisartan EP Impurity A (CAS CATO-C4X-135971)
- 1-Benzylimidazolidin-4-one (CAS 114981-11-2)
- 2,2-Bis(4-carbamoyl-3-nitrophenyl)hexafluoropropane (CAS 887267-99-4)
- 1-(4-Cyclopropylphenyl)-2,2,2-trifluoroethan-1-one (CAS 2168894-56-0)
- 2-(3,4-Dichlorophenyl)-N-[2-(phenylsulfanyl)ethyl]acetamide (CAS 477886-11-6)
- (R)-1,1-Bis(3,5-bis(trifluoromethyl)phenyl)tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one (CAS 1146629-85-7)
- 7-Chloro-[1,2,4]triazolo[4,3-a]pyrimidin-3(2H)-one (CAS 1020037-45-9)
- D-Pro36-Tirzepatide (CAS CATO-CPTD788903)
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