Tolvaptan Impurity 26 CAS 1580889-25-3
| CAS No. | 1580889-25-3 |
| Molecular Formula | C26H25ClN2O3 |
| Molecular Weight | 448.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tolvaptan Impurity 26 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Tolvaptan Impurity 26 (CAS 1580889-25-3), a pharmacopoeial impurity reference standard (molecular formula C26H25ClN2O3, MW 448.94 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C26H25ClN2O3, Tolvaptan Impurity 26 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 448.94 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Tolvaptan Impurity 26 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H25ClN2O3 |
| Molecular Weight | 448.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tolvaptan Standards
Recommended Standards
- 2-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-4-(4-methylphenyl)-1H,4H,5H-indeno[1,2-d]pyrimidin-5-one (CAS 691873-09-3)
- Azd3463 (CAS 1356962-20-3)
- 2-(((2-Chlorothiazol-5-yl)methyl)thio)-3-(furan-2-ylmethyl)-6,7-dimethoxyquinazolin-4(3H)-imine (CAS 477848-70-7)
- Lirequinil (CAS 143943-73-1)
- Cefcapene Impurity 70 (CAS CATO-C4X-182470)
- Cabazitaxel Impurity 43 (CAS CATO-C4X-111543)
- Donepezil Impurity 59 (CAS 120013-57-2)
- Nelarabine (CAS 121032-29-9)
- Ethyl 3-(hydroxymethyl)cyclohexane-1-carboxylate (CAS 190321-53-0)
- 2-(((3-Chloropyrazin-2-yl)methyl)(methyl)amino)ethanol (CAS 1353960-18-5)
- Tert-butyl ((1R,2R)-2-amino-1,2-diphenylethyl)carbamate (CAS 1227946-98-6)
- Ethyl 3-amino-3-ethylpentanoate (CAS 90727-07-4)
- Diethyl (4-bromo-2-cyanobenzyl)phosphonate (CAS 2211060-53-4)
- Semaglutide impurity 101 (CAS CATO-C4X-2226101)
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