Tolvaptan Impurity 69 CAS 1580889-27-5
| CAS No. | 1580889-27-5 |
| Molecular Formula | C26H25ClN2O3 |
| Molecular Weight | 448.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Tolvaptan Impurity 69 (CAS 1580889-27-5), a pharmacopoeial impurity reference standard (molecular formula C26H25ClN2O3, MW 448.94 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C26H25ClN2O3, Tolvaptan Impurity 69 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 448.94 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C26H25ClN2O3 |
| Molecular Weight | 448.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tolvaptan Standards
Recommended Standards
- Azd3463 (CAS 1356962-20-3)
- 2-(((2-Chlorothiazol-5-yl)methyl)thio)-3-(furan-2-ylmethyl)-6,7-dimethoxyquinazolin-4(3H)-imine (CAS 477848-70-7)
- N-(3-(1H-Imidazol-1-yl)propyl)-4-((4-chlorophenyl)sulfonyl)-2-(thiophen-2-yl)oxazol-5-amine (CAS 627835-01-2)
- 2-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}-4-(4-methylphenyl)-1H,4H,5H-indeno[1,2-d]pyrimidin-5-one (CAS 691873-09-3)
- Cefathiamidine Impurity 21 (CAS CATO-C4X-133721)
- Moxifloxacin impurity 161 (CAS 55698-67-4)
- Flurbiprofen Impurity 61 (CAS 95037-98-2)
- 1,2-Dichloro-4-iodo-5-methylbenzene (CAS 1806312-27-5)
- 5-(3-Phenylallylidene)-2-thioxoimidazolidin-4-one (CAS 53514-60-6)
- 3-Methoxy-N-methylaniline hydrochloride (CAS 26926-55-6)
- 3-(Furan-2-yl)-4-phenylbutan-1-amine (CAS 378773-15-0)
- 5-Chloro-2-(2-methoxy-ethoxy)-phenylamine (CAS 23987-21-5)
- 2-Amino-6-(4-methylpiperazin-1-yl)benzonitrile (CAS 63365-17-3)
- Semaglutide impurity 331 (CAS CATO-C4X-2226231)
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