Amlodipine Impurity 42 CAS 158151-92-9
| CAS No. | 158151-92-9 |
| Molecular Formula | C22H29ClN2O5 |
| Molecular Weight | 436.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Amlodipine Impurity 42.
Amlodipine Impurity 42 (CAS 158151-92-9) is a certified pharmaceutical impurity reference standard with the molecular formula C22H29ClN2O5 and a molecular weight of 436.93 g/mol.
The molecular framework of Amlodipine Impurity 42 (C22H29ClN2O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Amlodipine Impurity 42 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H29ClN2O5 |
| Molecular Weight | 436.93 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amlodipine Standards
- Amlodipine Impurity 43 (CAS CATO-C4X-109543)
- Amlodipine Impurity 51 (CAS 93848-81-8)
- Amlodipine Impurity 117 (CAS CATO-C4X-1095117)
- Amlodipine Impurity 133 (CAS CATO-C4X-1095133)
- Amlodipine Impurity 82 (CAS CATO-C4X-109582)
- Amlodipine Impurity 84 (CAS 906098-03-1)
- Amlodipine Azido Impurity (CAS 88150-46-3)
- Amlodipine Impurity 20 (CAS 400024-08-0)
Recommended Standards
- (2Z)-7-(4-Chlorophenoxy)-2-[(4-methylphenyl)methylidene]-3-phenyl-2,3-dihydro-1H-inden-1-one (CAS 337921-25-2)
- N-[3-[[4-(Chloromethyl)benzoyl]amino][1,1-biphenyl]-4-yl]carbamic Acid tert-Butyl Ester (CAS 1003316-10-6)
- Dapagliflozin Impurity 47 (CAS CATO-C4X-113847)
- N-(5-Chloro-2-methoxyphenyl)-2-((4-cyano-3-methylbenzo[4,5]imidazo[1,2-a]pyridin-1-yl)thio)acetamide (CAS 868357-74-8)
- Venetoclax Impurity 47 (CAS CATO-C4X-249547)
- Fluorouracil Impurity 20 (CAS CATO-C4X-164920)
- Upacicalcet Sodium Impurity 2 (CAS CATO-C4X-33922)
- RH 421 (CAS 107610-19-5)
- 2-((4-(4-Chlorophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(o-tolyl)acetamide (CAS 476484-03-4)
- Glabridin (CAS 59870-68-7)
- H-Ser-Leu-Ser-Leu-Ser-Pro-Gly-OH trifluoroacetate salt (CAS 943235-75-4)
- 3-(Methoxycarbonyl)-5-oxo-5H-thiazolo[3,2-a]pyridine-8-carboxylic acid (CAS 2387596-63-4)
- 3-Hydroxy-1,5-diphenylpentan-1-one (CAS 60669-64-9)
- Neuropeptide VF (124-131) (human) (CAS 311309-27-0)
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