Amlodipine Impurity 20 CAS 400024-08-0
| CAS No. | 400024-08-0 |
| Molecular Formula | C23H20ClNO6 |
| Molecular Weight | 441.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Amlodipine Impurity 20 (C23H20ClNO6) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Amlodipine Impurity 20 (CAS 400024-08-0) is a certified pharmaceutical impurity reference standard with the molecular formula C23H20ClNO6 and a molecular weight of 441.86 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H20ClNO6 |
| Molecular Weight | 441.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Amlodipine Standards
- Amlodipine Impurity 84 (CAS 906098-03-1)
- Amlodipine Impurity 117 (CAS CATO-C4X-1095117)
- Amlodipine Impurity 133 (CAS CATO-C4X-1095133)
- Amlodipine Impurity 82 (CAS CATO-C4X-109582)
- Amlodipine Impurity 42 (CAS 158151-92-9)
- Amlodipine Impurity 43 (CAS CATO-C4X-109543)
- Amlodipine Impurity 51 (CAS 93848-81-8)
- Amlodipine Impurity 17 (CAS CATO-C4X-109517)
Recommended Standards
- N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-((4-ethyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 573950-78-4)
- Lenvatinib Impurity 28 (CAS 417717-20-5)
- N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-((4-ethyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 573695-56-4)
- (3-(4-Aminophenyl)-5-methylisoxazol-4-yl)(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)methanone (CAS 1264870-22-5)
- Xylometazoline Impurity N1 (CAS 7364-19-4)
- Terbutaline Impurity 30 HBr (CAS CATO-C4X-118330)
- Finasteride Impurity 47 (CAS CATO-C4X-164547)
- 1-(difluoromethyl)-3-nitro-1H-indazole (CAS 1803599-67-8)
- Rel-(3aR,7aS)-octahydro-2H-isoindole-2-sulfonamide (CAS 26918-73-0)
- (E)-N'-carbamothioyl-N,N-dimethylformimidamide (CAS 83490-20-4)
- 1-(1,4-Diazepan-1-yl)-2,2-dimethylbutan-1-one (CAS 1240564-63-9)
- Dihydrocapsaicin (CAS 19408-84-5)
- 2-Hydroxy-2-methyl-3-phenylmethanesulfonyl-N-[3-(trifluoromethyl)phenyl]propanamide (CAS 339275-66-0)
- FMRF-Like Neuropeptide (CAS 121801-61-4)
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