3-(Difluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile CAS 1597952-88-9
| CAS No. | 1597952-88-9 |
| Molecular Formula | C8H4F2N4 |
| Molecular Weight | 194.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-(Difluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile (CAS 1597952-88-9), molecular formula C8H4F2N4 and molecular weight 194.14 g/mol, is a CATO reference standard with documented purity and traceability.
3-(Difluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile (C8H4F2N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 3-(Difluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4F2N4 |
| Molecular Weight | 194.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Difluoromethyl Standards
- 2-(difluoromethyl)benzo[d]oxazole-4-carbonitrile (CAS 1806282-45-0)
- 5-(Difluoromethyl)-1,3-difluoro-2-methoxybenzene (CAS 1261602-96-3)
- 1-(Difluoromethyl)-4,5-difluoro-2-methoxybenzene (CAS 1261875-42-6)
- (4-(Difluoromethyl)-2,5-difluorophenyl)methanol (CAS 1804418-98-1)
- (2-(Difluoromethyl)-3,5-difluoropyridin-4-yl)methanamine (CAS 1805332-14-2)
- (3-(Difluoromethyl)-2,6-difluoropyridin-4-yl)methanamine (CAS 1806023-17-5)
- 3-(Difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid (CAS 1255735-09-1)
- 3-(Difluoromethyl)-5-phenyl-1H-pyrazole (CAS 122980-86-3)
Recommended Standards
- 2-(5,6-Difluoro-2H-benzo[d][1,2,3]triazol-2-yl)acetonitrile (CAS 1553569-67-7)
- 4,5,7-Trihydroxy-2h-chromen-2-one (CAS 17575-26-7)
- DL-Galacturonic acid (CAS 14982-50-4)
- 8-Nitro-1H-benzo[d][1,3]oxazin-2(4H)-one (CAS 148890-66-8)
- 2-Morpholino-5-(trifluoromethyl)benzenesulfonyl chloride (CAS 906352-76-9)
- 2-methyl-3H-imidazo[4,5-b]pyridine-7-carboxylic acid (CAS 115951-61-6)
- (2-Fluoro-6-iodopyridin-4-yl)boronic acid (CAS 2225176-15-6)
- Ethyl 3-((2,2-dimethoxyethyl)amino)propanoate (CAS 198628-01-2)
- 2,2-difluoro-2-(1,3-thiazol-2-yl)ethan-1-ol (CAS 1803604-35-4)
- 3-(Furan-3-yl)-3-oxopropanenitrile (CAS 96220-13-2)
- Iopamidol Impurity 41 (CAS CATO-C4X-145041)
- 2-(Aminomethyl)-n-methyl-n-(propan-2-yl)aniline (CAS 1020969-82-7)
- GW 4064 (CAS 278779-30-9)
- Insulin Degludec Impurity 9 (CAS CATO-C4X-21579)
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