Topiroxostat Impurity 66 CAS 159890-49-0
| CAS No. | 159890-49-0 |
| Molecular Formula | C6H8N4O |
| Molecular Weight | 152.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Topiroxostat Impurity 66 is closely related to an amide group, a hydroxyl group, an ether linkage, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Topiroxostat Impurity 66 (CAS 159890-49-0, C6H8N4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Topiroxostat Impurity 66 (C6H8N4O) is characterized by an amide group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Topiroxostat Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H8N4O |
| Molecular Weight | 152.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Nitrogen Atoms | 4 |
Related Topiroxostat Standards
- Topiroxostat Impurity 1 (CAS 3783-38-8)
- Topiroxostat Impurity 5 (CAS 6975-73-1)
- Topiroxostat Impurity 45 (CAS 161233-97-2)
- Topiroxostat Impurity 51 (CAS 98273-47-3)
- Topiroxostat Impurity 12 (CAS 94413-64-6)
- Topiroxostat Impurity 13 (CAS 135048-32-7)
- Topiroxostat Impurity 40 (CAS 1824131-48-7)
- Topiroxostat Impurity 41 (CAS CATO-C4X-105541)
Recommended Standards
- Apremilast Impurity 120 (CAS 621-59-0)
- Linezolid Impurity 39 (CAS 39608-52-1)
- Methyl 3-Hydroxybenzoate (CAS 19438-10-9)
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- Letrozole Impurity 12 (CAS CATO-C4X-182912)
- Lenvatinib Impurity 180 (CAS CATO-C4X-1140180)
- Lifitegrast Impurity 75 (CAS CATO-C4X-240975)
- 1-(2-Methylquinolin-4-yl)piperidin-4-ol (CAS 927801-80-7)
- Gliclazide (CAS 21187-98-4)
- (2E)-N-(5-Fluoro-2-methylphenyl)-3-[4-(2-methylpropyl)phenyl]prop-2-enamide (CAS 329778-60-1)
- 22258-56-6 4-(1H-indol-3-yl)-1,3-thiazol-2-amine DTXSID90355536 (CAS 22258-56-6)
- 1-[(3,5-Dimethylphenyl)methoxy]-2-(4-methoxyphenyl)-1H-1,3-benzodiazole (CAS 400086-37-5)
- 3-Cyclopropoxy-2,6-diisopropoxypyridine (CAS 1243373-63-8)
- C-Peptide 1 (rat) (CAS 41475-27-8)
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