Topiroxostat Impurity 45 CAS 161233-97-2
| CAS No. | 161233-97-2 |
| Molecular Formula | C7H4N2O2 |
| Molecular Weight | 148.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Topiroxostat Impurity 45 (CAS 161233-97-2, C7H4N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage, Topiroxostat Impurity 45 is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 148.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4N2O2 |
| Molecular Weight | 148.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Nitrogen Atoms | 2 |
Related Topiroxostat Standards
- Topiroxostat Impurity 51 (CAS 98273-47-3)
- Topiroxostat Impurity 66 (CAS 159890-49-0)
- Topiroxostat Impurity 1 (CAS 3783-38-8)
- Topiroxostat Impurity 5 (CAS 6975-73-1)
- Topiroxostat Impurity 3 (CAS 13602-12-5)
- Topiroxostat Impurity 4 (CAS 2459-09-8)
- Topiroxostat Impurity 47 (CAS 93-60-7)
- Topiroxostat Impurity 6 (CAS 54-85-3)
Recommended Standards
- 3-Nitrobenzonitrile (CAS 12402-46-9)
- L-GLUTAMIC ACID-15N (CAS 21160-87-2)
- 1-Nitroso-1H-benzotriazole (CAS 23351-96-4)
- 4-Nitrobenzonitrile (CAS 619-72-7)
- Benidipine Impurity 8 (CAS CATO-C4X-11208)
- Benserazide EP Impurity A (CAS 64616-76-8)
- Semaglutide Impurity 129 (CAS 2490269-79-7)
- 4-Methoxy-2-(trifluoromethoxy)benzylamine (CAS 1159512-67-0)
- Bis(hexafluoroacetylacetonato)cobalt(II) (CAS 19648-83-0)
- (E)-3-(6-Methyl-1H-indol-3-yl)acrylic acid (CAS 151590-36-2)
- 3-(3-Methoxypropoxy)azetidine trifluoroacetate (CAS 1820736-22-8)
- 2-Allyl-2-phenylpent-4-enamide (CAS 3563-57-3)
- 3-(4-Tert-butylphenyl)-2-methylpropanoic acid (CAS 66735-04-4)
- Peptide WE-14 (CAS 115136-18-0)
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