N-(3-Chloro-4-cyano-5-isothiazolyl)-3-methylbenzenecarboxamide CAS 159978-14-0

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(3-Chloro-4-cyano-5-isothiazolyl)-3-methylbenzenecarboxamide.

N-(3-Chloro-4-cyano-5-isothiazolyl)-3-methylbenzenecarboxamide (CAS 159978-14-0), molecular formula C12H8ClN3OS and molecular weight 277.73 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of N-(3-Chloro-4-cyano-5-isothiazolyl)-3-methylbenzenecarboxamide (C12H8ClN3OS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

CATO manufactures N-(3-Chloro-4-cyano-5-isothiazolyl)-3-methylbenzenecarboxamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

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