Lenvatinib Impurity 130 CAS 16026-77-0

Description

Compared with other compounds in its class, the molecular weight of 143.57 g/mol gives Lenvatinib Impurity 130 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

As a process- or degradation-related impurity, Lenvatinib Impurity 130 (CAS 16026-77-0, C6H6ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Lenvatinib Impurity 130 (C6H6ClNO) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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