Lenvatinib Impurity 33 CAS 3964-52-1
| CAS No. | 3964-52-1 |
| Molecular Formula | C6H6ClNO |
| Molecular Weight | 143.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Lenvatinib Impurity 33 (C6H6ClNO) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Lenvatinib Impurity 33 (CAS 3964-52-1, C6H6ClNO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lenvatinib Impurity 33 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6ClNO |
| Molecular Weight | 143.57 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Lenvatinib Standards
- Lenvatinib Impurity 130 (CAS 16026-77-0)
- Lenvatinib Impurity 132 (CAS 56962-01-7)
- Lenvatinib Impurity 68 (CAS 17609-80-2)
- Lenvatinib Impurity 119 (CAS CATO-C4X-1140119)
- Lenvatinib Impurity 121 (CAS CATO-C4X-1140121)
- Lenvatinib Impurity 69 (CAS 615-66-7)
- Lenvatinib Impurity 83 (CAS 56766-77-9)
- Lenvatinib Impurity 16 (CAS 69332-65-6)
Recommended Standards
- Chlorzoxazone USP Related Compound A (CAS 95-85-2)
- Gadobutrol Impurity 110 (CAS 28443-50-7)
- 3-Chloro-2-hydrazinopyridine (CAS 22841-92-5)
- 2-Chloro-5-aminophenol (CAS 6358-06-1)
- Pitolisant impurity 17 (CAS CATO-C4X-252017)
- Abemaciclib Impurity 80 (CAS CATO-C4X-293780)
- Mirogabalin Impurity 129 (CAS CATO-C4X-2924129)
- methyl 3-(chlorosulfonyl)-4-methylthiophene-2-carboxylate (CAS 190375-00-9)
- 2-(2,6-Difluorophenyl)-2,2-difluoroacetic acid (CAS 1344264-52-3)
- Ethylene Glycol Impurity 1 (Ethylene Glycol Monoformate) (CAS 628-35-3)
- 4-(3-Bromophenyl)-4,5,6,7-tetrahydro-3h-imidazo[4,5-c]pyridine (CAS 7271-10-5)
- 2-{4-chlorothieno[2,3-d]pyrimidin-2-yl}pyridine (CAS 56843-81-3)
- 3-Chloro-1-methyl-1H-pyrazol-4-ol (CAS 2685800-18-2)
- Semaglutide Impurity 246 (CAS CATO-C4X-2226246)
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