Isosorbide Dinitrate, Diluted EP Impurity C CAS 16051-77-7
| CAS No. | 16051-77-7 |
| Molecular Formula | C6H9NO6 |
| Molecular Weight | 191.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Isosorbide Dinitrate, Diluted EP Impurity C (CAS 16051-77-7), a pharmacopoeial impurity reference standard (molecular formula C6H9NO6, MW 191.14 g/mol) used for the identification and quantification of trace impurities in APIs.
Isosorbide Dinitrate, Diluted EP Impurity C (C6H9NO6) contains a carbohydrate-derived structure, an amide group. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H9NO6 |
| Molecular Weight | 191.14 g/mol |
| Appearance | White to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 1 |
Related Isosorbide Standards
- Isosorbide Dinitrate Impurity 18 (Diluted with Lactose) (CAS 16908-90-0)
- Isosorbide Dinitrate EP Impurity B (CAS 16106-20-0)
- Isosorbide Dinitrate Impurity 28 (CAS CATO-C4X-223828)
- Isosorbide Dinitrate Impurity 10 (CAS CATO-C4X-223810)
- Isosorbide Dinitrate Impurity 11 (CAS 110627-22-0)
- Isosorbide Impurity 22 (CAS 110627-23-1)
- Isosorbide Dinitrate Impurity 5 (CAS 13042-39-2)
- Isosorbide Dinitrate Impurity 6 (CAS 65940-93-4)
Recommended Standards
- Levodopa Impurity 14 (CAS 161940-76-7)
- L-Isoidide Mononitrate (Diluted with Lactose) (CAS 16908-91-1)
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- 1-Nitroso-1H-indazole-3-carboxylic Acid (CAS CATO-C3D-26200)
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