Tofacitinib Impurity 7 CAS 1616761-00-2
| CAS No. | 1616761-00-2 |
| Molecular Formula | C16H19ClN6O |
| Molecular Weight | 346.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Tofacitinib Impurity 7 (CAS 1616761-00-2, C16H19ClN6O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tofacitinib Impurity 7 (C16H19ClN6O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Tofacitinib Impurity 7 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H19ClN6O |
| Molecular Weight | 346.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Tofacitinib Standards
- Tofacitinib Impurity 21 (CAS CATO-C4X-107921)
- Tofacitinib Impurity 250 (CAS CATO-C4X-1079250)
- Tofacitinib Impurity 226 (CAS 2101951-13-5)
- Tofacitinib Impurity 234 (CAS CATO-C4X-1079234)
- Tofacitinib Impurity 249 (CAS CATO-C4X-1079249)
- Tofacitinib Impurity 58 (CAS CATO-C4X-107958)
- Tofacitinib Impurity 112 (CAS CATO-C4X-1079112)
- Tofacitinib Impurity 209 (CAS CATO-C4X-1079209)
Recommended Standards
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- Sildenafil Impurity 265 (CAS 1829588-57-9)
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- Sildenafil Impurity 266 (CAS CATO-C4X-1128266)
- Proparacaine Impurity 8 HCl (CAS 35288-46-1)
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- Methyl 2-(2-chloroacetamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate (CAS 300559-61-9)
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