Tofacitinib Impurity 150 CAS 1616761-01-3
| CAS No. | 1616761-01-3 |
| Molecular Formula | C18H25N5O3 |
| Molecular Weight | 359.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tofacitinib Impurity 150 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Tofacitinib Impurity 150 (CAS 1616761-01-3), a pharmacopoeial impurity reference standard (molecular formula C18H25N5O3, MW 359.42 g/mol) used for the identification and quantification of trace impurities in APIs.
Tofacitinib Impurity 150 (C18H25N5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C18H25N5O3 |
| Molecular Weight | 359.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 5 |
Related Tofacitinib Standards
- Tofacitinib Impurity 84 (CAS 1675248-18-6)
- Tofacitinib Impurity 51 (CAS 2504210-38-0)
- Tofacitinib Impurity 138 (CAS CATO-C4X-1079138)
- Tofacitinib Impurity 85 (CAS CATO-C4X-107985)
- Tofacitinib Impurity 202 (CAS CATO-C4X-1079202)
- Tofacitinib Impurity 132 (CAS CATO-C4X-1079132)
- Tofacitinib Impurity 112 (CAS CATO-C4X-1079112)
- Tofacitinib Impurity 134 (CAS CATO-C4X-1079134)
Recommended Standards
- Crizotinib impurity 17 (CAS 2322541-37-5)
- Vonoprazan Impurity 101 (CAS 1885094-62-1)
- Terbutaline impurity 110 (CAS CATO-C4X-1183110)
- tert-butyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethyl)piperazine-1-carboxylate (CAS 227776-28-5)
- Spironolactone Impurity 19 (CAS CATO-C4X-134519)
- Cefpodoxime Proxetil EP Impurity C (CAS 339528-86-8)
- Loxoprofen Impurity 131 (CAS CATO-C4X-1488131)
- Loxoprofen Impurity 25 (CAS 1091621-63-4)
- 2-(Pentan-2-yl)isoindoline-1,3-dione (CAS 61345-59-3)
- 2-(((1-(tert-Butoxycarbonyl)pyrrolidin-3-yl)methyl)(isopropyl)amino)acetic acid (CAS 1353946-11-8)
- 4-Fluoro-5-iodo-1H-indazole (CAS 1082041-87-9)
- 5-Bromo-6-azaindole-3-carbaldehyde (CAS 1369348-93-5)
- (S)-2-Amino-N-(1-benzyl-piperidin-2-ylmethyl)-N-ethyl-propionamide (CAS 1354025-00-5)
- Glucagon (19-29) (human, rat, porcine) (CAS 64790-15-4)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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