Dabrafenib Impurity 18 CAS 1622082-84-1
| CAS No. | 1622082-84-1 |
| Molecular Formula | C18H10BrClF3N3O3S |
| Molecular Weight | 520.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 520.71 g/mol gives Dabrafenib Impurity 18 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Dabrafenib Impurity 18 (CAS 1622082-84-1) is a certified pharmaceutical impurity reference standard with the molecular formula C18H10BrClF3N3O3S and a molecular weight of 520.71 g/mol.
The molecular framework of Dabrafenib Impurity 18 (C18H10BrClF3N3O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dabrafenib Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H10BrClF3N3O3S |
| Molecular Weight | 520.71 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Dabrafenib Standards
- Dabrafenib Impurity 30 (CAS CATO-C4X-303330)
- Dabrafenib Impurity 26 (CAS CATO-C4X-303326)
- Dabrafenib (CAS 1195765-45-7)
- Dabrafenib Impurity 40 (CAS CATO-C4X-303340)
- Dabrafenib Impurity 1 (CAS 2017554-98-0)
- Dabrafenib Impurity 13 (CAS CATO-C4X-303313)
- Dabrafenib Impurity 24 (CAS CATO-C4X-303324)
- Dabrafenib Impurity 2 (CAS CATO-C4X-30332)
Recommended Standards
- 2-((4-(2,6-Di(pyrrolidin-1-yl)pyrimidin-4-yl)piperazin-1-yl)methyl)-2,5,7,8-tetramethylchroman-6-ol (CAS 122003-11-6)
- Dipyridamole-d16 (CAS CATO-C4X-161810)
- Platycodigenin (CAS 22327-82-8)
- 2,3-Bis(decyloxy)anthracene-9,10-dione (CAS 140844-73-1)
- Rivaroxaban Impurity 139 (CAS 85-41-6)
- Tobramycin Impurity 3 (CAS CATO-C4X-22003)
- Naltrexone impurity 48 (CAS CATO-C4X-147548)
- Butyl-d9 Paraben (CAS 1216904-65-2)
- 6-Nitro-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine (CAS 80773-01-9)
- 3-Chloro-2-fluoro-6-(trifluoromethyl)benzylamine (CAS 261763-08-0)
- 2-((3-Cyanothiophen-2-yl)amino)-2-oxoethyl 2-(3-(trifluoromethyl)phenyl)acetate (CAS 338777-44-9)
- methyl 3-(3,4-dimethylphenyl)-1H-pyrazole-5-carboxylate (CAS 192701-98-7)
- 2-(1-(4-Methoxybenzyl)-1H-pyrazol-4-yl)acetic acid (CAS 1445951-84-7)
- Semaglutide impurity 25 (CAS CATO-C4X-222625)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com