2-Chloro-N4-(4-chloro-3-fluoro-phenyl)-pyrimidine-4,5-diamine CAS 1627180-67-9
| CAS No. | 1627180-67-9 |
| Molecular Formula | C10H7Cl2FN4 |
| Molecular Weight | 273.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-Chloro-N4-(4-chloro-3-fluoro-phenyl)-pyrimidine-4,5-diamine (CAS 1627180-67-9), a certified reference material (molecular formula C10H7Cl2FN4, MW 273.09 g/mol) for analytical method development and quality control.
Structurally, 2-Chloro-N4-(4-chloro-3-fluoro-phenyl)-pyrimidine-4,5-diamine (C10H7Cl2FN4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 273.09 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7Cl2FN4 |
| Molecular Weight | 273.09 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- 4-Chloro-2-(5-chloro-2-fluorophenyl)-5-methoxypyrimidine (CAS 674793-47-6)
- 4-Chloro-2-(2-chloro-1,1,1-trifluoropropan-2-yl)-1-methoxybenzene (CAS 1402004-23-2)
- Methyl 5-chloro-2-(3-chloropyridin-2-yl)-2H-1,2,3-triazole-4-carboxylate (CAS 1774899-17-0)
- 2-Chloro-3-(chlorosulfonyl)-5-fluorobenzoic acid (CAS 1242338-93-7)
- 3-chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid (CAS 1242339-12-3)
- 4-Chloro-3-(chlorosulfonyl)-5-fluorobenzoic acid (CAS 1242339-73-6)
- 2-chloro-5-(chlorosulfonyl)-3-fluorobenzoic acid (CAS 766532-96-1)
- 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoic acid (CAS 264927-50-6)
Recommended Standards
- 3,5-Dichloro-6-(2-fluorophenyl)-1-methylpyrazin-2(1H)-one (CAS 1269533-60-9)
- (5-(N-Cyclopropylsulfamoyl)-2-fluoro-4-methylphenyl)boronic acid (CAS 1704121-43-6)
- 3,5-Dichloro-6-(4-fluorophenyl)-1-methylpyrazin-2(1H)-one (CAS 1269530-80-4)
- (4-Fluoro-3-(pyrrolidin-1-ylsulfonyl)phenyl)boronic acid (CAS 1704121-54-9)
- (2-Cyclopentylpyridin-4-yl)boronic acid (CAS 2225172-93-8)
- 5-Chloro-2,3,6-trifluorobenzotrifluoride (CAS 122030-03-9)
- 1-Cyclopropylpiperazine (CAS 20327-23-5)
- 8-chloro-2-methoxy-1,5-naphthyridine (CAS 249889-68-7)
- 5-Nitro-2-(piperidine-1-yl)pyridine (CAS 1233951-55-7)
- methyl 2-[5-(difluoromethyl)-1,3,4-oxadiazol-2-yl]acetate (CAS 1798713-42-4)
- Cefixime Impurity 78 (CAS CATO-C4X-113978)
- Nonanehydrazide (CAS 3338-51-0)
- 2,4,7-Trimethylbenzo[b]thiophene-3-sulfonamide (CAS 1384429-69-9)
- Peptide Impurity 81 TFA (CAS CATO-CPTD788581)
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