Alogliptin Impurity 1 CAS 1638544-64-5
| CAS No. | 1638544-64-5 |
| Molecular Formula | C18H21N5O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Alogliptin Impurity 1 (CAS 1638544-64-5, C18H21N5O2C7H6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C18H21N5O2C7H6O2, Alogliptin Impurity 1 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 461.52 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Alogliptin Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H21N5O2 C7H6O2 |
| Molecular Weight | 461.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 5 |
Related Alogliptin Standards
- Alogliptin Impurity 3 (CAS 1108731-49-2)
- Alogliptin Impurity 89 (CAS 1108732-05-3)
- Alogliptin impurity 77 HCl (CAS 1108732-05-3（free base）)
- Alogliptin Impurity 51 (CAS 1133421-35-8)
- Alogliptin Impurity 38 (CAS 120977-94-8)
- Alogliptin Impurity 16 (CAS 1217476-03-3)
- Alogliptin Impurity 33 (CAS 123-56-8)
- Alogliptin Impurity 69 (CAS 1243378-31-5)
Recommended Standards
- Formoterol Impurity 59 (CAS 306966-56-3)
- Cefixime Impurity 90 (CAS CATO-C4X-113990)
- Phloroglucinol Impurity 74 (CAS CATO-C4X-221774)
- (1E,4E)-1,5-diethoxypenta-1,4-dien-3-one (CAS 135203-27-9)
- 7-Phenyl-3h,4h,7h-pyrazolo[3,4-d][1,2,3]triazin-4-one (CAS 114163-48-3)
- Lithium tartrate monohydrate (CAS 6108-32-3)
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- 6-Isobutoxypyrimidine-4-carboxylic acid (CAS 1439902-87-0)
- tert-butyl N-[3-oxo-2-(pyridin-3-ylmethyl)propyl]carbamate (CAS 1798717-56-2)
- Tyr-Proinsulin C-Peptide (55-89) (human) (CAS 139532-11-9)
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